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Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art.
Solid lipid nanoparticles (SLN) introduced in 1991 represent an alternative carrier system to traditional colloidal carriers, such as emulsions, liposomes and polymeric micro- and nanoparticles. SLNExpand
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Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations.
Solid lipid nanoparticles (SLN) were developed at the beginning of the 1990 s as an alternative carrier system to emulsions, liposomes and polymeric nanoparticles. The paper reviews advantages-alsoExpand
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Lipid nanoparticles (SLN, NLC) in cosmetic and pharmaceutical dermal products.
Solid lipid nanoparticles (SLN) are distinguishable from nanostructured lipid carriers (NLC) by the composition of the solid particle matrix. Both are an alternative carrier system to liposomes andExpand
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Nanostructured lipid matrices for improved microencapsulation of drugs.
At the beginning of the nineties solid lipid nanoparticles (SLN) have been introduced as a novel nanoparticulate delivery system produced from solid lipids. Potential problems associated with SLNExpand
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Solid lipid nanoparticles for parenteral drug delivery.
This review describes the use of nanoparticles based on solid lipids for the parenteral application of drugs. Firstly, different types of nanoparticles based on solid lipids such as "solid lipidExpand
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Nanosuspensions as particulate drug formulations in therapy. Rationale for development and what we can expect for the future.
An increasing number of newly developed drugs are poorly soluble; in many cases drugs are poorly soluble in both aqueous and organic media excluding the traditional approaches of overcoming suchExpand
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Nanocrystal technology, drug delivery and clinical applications
Nanotechnology will affect our lives tremendously over the next decade in very different fields, including medicine and pharmacy. Transfer of materials into the nanodimension changes their physicalExpand
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A critical discussion of intraclass correlation coefficients.
In general, intraclass correlation coefficients (ICC's) are designed to assess consistency or conformity between two or more quantitative measurements. They are claimed to handle a wide range ofExpand
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Nanocrystals: industrially feasible multifunctional formulation technology for poorly soluble actives.
Nanocrystals being a kind of "universal" formulation approach for these molecules are reviewed in this paper regarding the industrial feasibility, i.e. industrially available production processes (bottom-up and top-down technologies). Expand
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Drug nanocrystals of poorly soluble drugs produced by high pressure homogenisation.
For many new chemical entities (NCE) of very low solubility oral bioavailability enhancement by micronisation is not sufficient, the next step taken was nanonisation. The production of drugExpand
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