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Place navigation impaired in rats with hippocampal lesions
Electrophysiological studies have shown that single cells in the hippocampus respond during spatial learning and exploration1–4, some firing only when animals enter specific and restricted areas of aExpand
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Synaptic tagging and long-term potentiation
Repeated stimulation of hippocampal neurons can induce an immediate and prolonged increase in synaptic strength that is called long-term potentiation (LTP)—the primary cellular model of memory in theExpand
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Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5
Recent work has shown that the hippocampus contains a class of receptors for the excitatory amino acid glutamate that are activated by N-methyl-D-aspartate (NMDA)1 and that exhibit a peculiarExpand
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Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein
Specific patterns of neuronal firing induce changes in synaptic strength that may contribute to learning and memory. If the postsynaptic NMDA (N-methyl-D-aspartate) receptors are blocked, long-termExpand
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Hippocampal synaptic enhancement and information storage within a distributed memory system
Abstract The hypothesis that the physical substrate of memory in the mammalian brain resides in alterations of synaptic efficacy has been proposed frequently in both neuroscience 1–5 and cognitiveExpand
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A learning deficit related to age and β-amyloid plaques in a mouse model of Alzheimer's disease
Mice that overexpress the human mutant amyloid precursor protein (hAPP) show learning deficits, but the apparent lack of a relationship between these deficits and the progressive β-amyloid plaqueExpand
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Synaptic tagging: implications for late maintenance of hippocampal long-term potentiation
A novel property of hippocampal LTP, 'variable persistence', has recently been described that is, we argue, relevant to the role of LTP in information storage. Specifically, new results indicate thatExpand
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Making memories last: the synaptic tagging and capture hypothesis
The synaptic tagging and capture hypothesis of protein synthesis-dependent long-term potentiation asserts that the induction of synaptic potentiation creates only the potential for a lasting changeExpand
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Distinct components of spatial learning revealed by prior training and NMDA receptor blockade
SYNAPTIC plasticity dependent on N-methyl-D-aspartate (NMDA) receptors is thought to underlie certain types of learning and memory1–3. In support of this, both hippocampal long-term potentiation andExpand
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Weak before strong: dissociating synaptic tagging and plasticity-factor accounts of late-LTP
Experiments were conducted using hippocampal slices in vitro to compare two accounts of the mechanisms by which input-specific protein synthesis-dependent long-term potentiation (late-LTP) may beExpand
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