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The native anti-glucocorticoid paradigm
Neurosteroid metabolism. 7 alpha-Hydroxylation of dehydroepiandrosterone and pregnenolone by rat brain microsomes.
The quantitatively important metabolism to 7 alpha-OH compounds may contribute to the control of neurosteroid activity in brain, and derivatives of DHEA and PREG are known to be neuroactive.
The 7alpha-hydroxysteroids produced in human tonsils enhance the immune response to tetanus toxoid and Bordetella pertussis antigens.
Studies of the enzyme complex responsible for pregnenolone and dehydroepiandrosterone 7α-hydroxylation in mouse tissues
Neurosteroids: Cerebrospinal fluid levels for Alzheimer's disease and vascular dementia diagnostics.
- Sae-Bom Kim, M. Hill, Y. Kwak, R. Hampl, D. Jo, R. Morfin
- Biology, ChemistryThe Journal of clinical endocrinology and…
- 1 November 2003
A neurodegenerative disease such as Alzheimer's disease (AD) is associated with significantly higher dehydroepiandrosterone (DHEA) levels in cerebrospinal fluid (CSF). Because the human brain is…
Radioimmunoassay for Zearalenone and Zearalanol in Human Serum: Production, Properties, and Use of Porcine Antibodies
To produce antigens susceptible to raise antibodies for resorcylic acid lactones, the 6′-carboxymethyloxime derivatives of zearalenone and zearalanone were bound to bovine serum albumin. Pigs could…
Pregnenolone and dehydroepiandrosterone as precursors of native 7-hydroxylated metabolites which increase the immune response in mice
Neurosteroid 7-hydroxylation products in the brain.
Inter-conversion of 7α- and 7β-hydroxy-dehydroepiandrosterone by the human 11β-hydroxysteroid dehydrogenase type 1
HUMAN LIVER S9 FRACTIONS: METABOLISM OF DEHYDROEPIANDROSTERONE, EPIANDROSTERONE, AND RELATED 7-HYDROXYLATED DERIVATIVES
Assessment of cofactor dependence and metabolism of DHEA, EpiA, and their 7-hydroxylated derivatives in S9 fractions of human liver determined the presence of enzymes responsible for the 7α- and 16α-hydroxyation in the human liver and the reduction of 17-oxo-steroids into 17β-Hydroxysteroids.