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The native anti-glucocorticoid paradigm
Neurosteroid metabolism. 7 alpha-Hydroxylation of dehydroepiandrosterone and pregnenolone by rat brain microsomes.
TLDR
The quantitatively important metabolism to 7 alpha-OH compounds may contribute to the control of neurosteroid activity in brain, and derivatives of DHEA and PREG are known to be neuroactive.
Neurosteroids: Cerebrospinal fluid levels for Alzheimer's disease and vascular dementia diagnostics.
A neurodegenerative disease such as Alzheimer's disease (AD) is associated with significantly higher dehydroepiandrosterone (DHEA) levels in cerebrospinal fluid (CSF). Because the human brain is
Radioimmunoassay for Zearalenone and Zearalanol in Human Serum: Production, Properties, and Use of Porcine Antibodies
To produce antigens susceptible to raise antibodies for resorcylic acid lactones, the 6′-carboxymethyloxime derivatives of zearalenone and zearalanone were bound to bovine serum albumin. Pigs could
Neurosteroid 7-hydroxylation products in the brain.
HUMAN LIVER S9 FRACTIONS: METABOLISM OF DEHYDROEPIANDROSTERONE, EPIANDROSTERONE, AND RELATED 7-HYDROXYLATED DERIVATIVES
TLDR
Assessment of cofactor dependence and metabolism of DHEA, EpiA, and their 7-hydroxylated derivatives in S9 fractions of human liver determined the presence of enzymes responsible for the 7α- and 16α-hydroxyation in the human liver and the reduction of 17-oxo-steroids into 17β-Hydroxysteroids.
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