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Peginterferon-alfa2a plus ribavirin for 48 versus 72 weeks in patients with detectable hepatitis C virus RNA at week 4 of treatment.
TLDR
Extension of treatment with peginterferon-alfa2a plus ribavirin from 48 to 72 weeks significantly increases the rate of SVR in patients with detectable viremia at week 4 of treatment. Expand
Approach to the pathogenesis and treatment of nonalcoholic steatohepatitis.
TLDR
Therapeutic strategies aimed at modulating insulin resistance, normalizing lipoprotein metabolism, and downregulating inflammatory mediators with probiotics have promising potential. Expand
Peginterferon alfa-2b and ribavirin: effective in patients with hepatitis C who failed interferon alfa/ribavirin therapy.
TLDR
Peginterferon alfa-2b plus weight-based ribavirin is effective and safe in patients who failed interferonAlfa/ribavirin therapy andGenotype, baseline viral load, and fibrosis stage were predictors of response. Expand
Angiogenesis in chronic inflammatory liver disease
TLDR
This review examines the potential pathogenetic role of angiogenesis in the context of viral hepatitis, cirrhosis, autoimmune hepatitis, primary biliary cirrhotic disease, and alcoholic liver disease. Expand
Prevalence of hepatitis C virus infection in B-cell non-Hodgkin's lymphoma: systematic review and meta-analysis.
TLDR
HCV prevalence in patients with B-NHL is approximately 15%, higher than that reported not only in general population but also in Patients with other hematologic malignancies, suggesting a role of HCV in the etiology of B-nHL. Expand
The hepatitis B virus X protein up‐regulates tumor necrosis factor α gene expression in hepatocytes
TLDR
Results indicate that the hepatocyte TNF‐α synthesis induced by HBV is transcriptionally up‐regulated by HBx, which may have a role in the induction of the intrahepatic inflammatory processes that take place during acute and chronic hepatitis B. Expand
Induction of tumor necrosis factor alpha production by human hepatocytes in chronic viral hepatitis
TLDR
It is demonstrated that viral infection induces, both in vivo and in vitro, TNF-alpha production in hepatocytes, and indicated that the HBV X protein may regulate the expression of this cytokine. Expand
Characterization of pathogenic and prognostic factors of nonalcoholic steatohepatitis associated with obesity.
TLDR
Obese persons with higher age, with greater degrees of hepatic steatosis, and specially those with increased grades of intrahepatic inflammation have the greatest risk for progression to fibrotic liver disease. Expand
Thyroid autoimmune disorders in patients with chronic hepatitis C before and during interferon‐α therapy
TLDR
The prevalence of thyroid autoantibodies and autoimmune thyroid disorders in patients with chronic hepatitis C before and during interferon therapy is assessed. Expand
Risk of cirrhosis-related complications in patients with advanced fibrosis following hepatitis C virus eradication.
TLDR
Patients with HCV-induced cirrhosis and SVR showed an annual risk of approximately 1% for HCC and 2% for clinical disease progression, therefore, to prevent HCC surveillance, chronic HCV infection should preferably be treated before Cirrhosis has developed. Expand
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