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Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential.
Alpha-lipoic acid (LA) has become a common ingredient in multivitamin formulas, anti-aging supplements, and even pet food. It is well-defined as a therapy for preventing diabetic polyneuropathies,Expand
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Is α‐lipoic acid a scavenger of reactive oxygen species in vivo? Evidence for its initiation of stress signaling pathways that promote endogenous antioxidant capacity
The chemical reduction and oxidation (redox) properties of α‐lipoic acid (LA) suggest that it may have potent antioxidant potential. A significant number of studies now show that LA and its reducedExpand
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The effect of vitamins C and E in (n-3) highly unsaturated fatty acids-enriched Artemia nauplii on growth, survival, and stress resistance of fresh water walleye Stizostedion vitreum larvae
This study aimed to evaluate the effect of enriching Artemia nauplii with vitamin C (ascorbyl-6 palmitate) or vitamin E (α-tocopherol acetate), 20% w/w, together with a mixture of concentratedExpand
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Mitochondrial Decay in the Aging Rat Heart
Mitochondrial decay has been postulated to be a significant underlying part of the aging process. Decline in mitochondrial function may lead to cellular energy deficits, especially in times ofExpand
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Lipoic acid improves hypertriglyceridemia by stimulating triacylglycerol clearance and downregulating liver triacylglycerol secretion.
Elevated blood triacylglycerol (TG) is a significant contributing factor to the current epidemic of obesity-related health disorders, including type-2 diabetes, nonalcoholic fatty liver disease, andExpand
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Suppression of NLRP3 inflammasome by γ-tocotrienol ameliorates type 2 diabetes[S]
The Nod-like receptor 3 (NLRP3) inflammasome is an intracellular sensor that sets off the innate immune system in response to microbial-derived and endogenous metabolic danger signals. We previouslyExpand
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Dietary supplementation with (R)-α-lipoic acid reverses the age-related accumulation of iron and depletion of antioxidants in the rat cerebral cortex
Abstract Accumulation of divalent metal ions (e.g. iron and copper) has been proposed to contribute to heightened oxidative stress evident in aging and neurodegenerative disorders. To understand theExpand
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Characteristics of the rat cardiac sphingolipid pool in two mitochondrial subpopulations.
Mitochondrial sphingolipids play a diverse role in normal cardiac function and diseases, yet a precise quantification of cardiac mitochondrial sphingolipids has never been performed. Therefore, ratExpand
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La formation des équipes d'entrepreneurs
Sur quels principes se fondent les associations entre les membres d’une equipe d’entrepreneurs ? Partant de cette question, le present article commence par expliquer ce qu’est l’entrepreneuriatExpand
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Mitochondrial decay in the aging rat heart: evidence for improvement by dietary supplementation with acetyl-L-carnitine and/or lipoic acid.
Mitochondrial decay has been postulated to be a significant underlying part of the aging process. Decline in mitochondrial function may lead to cellular energy deficits, especially in times ofExpand
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