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- Publications
- Influence
Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential.
- K. P. Shay, R. Moreau, E. J. Smith, A. R. Smith, T. Hagen
- Biology, Medicine
- Biochimica et biophysica acta
- 1 October 2009
Alpha-lipoic acid (LA) has become a common ingredient in multivitamin formulas, anti-aging supplements, and even pet food. It is well-defined as a therapy for preventing diabetic polyneuropathies,… Expand
Is α‐lipoic acid a scavenger of reactive oxygen species in vivo? Evidence for its initiation of stress signaling pathways that promote endogenous antioxidant capacity
- Kate Petersen Shay, R. Moreau, Eric J Smith, T. Hagen
- Chemistry, Medicine
- IUBMB life
- 1 June 2008
The chemical reduction and oxidation (redox) properties of α‐lipoic acid (LA) suggest that it may have potent antioxidant potential. A significant number of studies now show that LA and its reduced… Expand
The effect of vitamins C and E in (n-3) highly unsaturated fatty acids-enriched Artemia nauplii on growth, survival, and stress resistance of fresh water walleye Stizostedion vitreum larvae
- S. Kolkovski, S. Czesny, +4 authors K. Dąbrowski
- Biology
- 1 September 2000
This study aimed to evaluate the effect of enriching Artemia nauplii with vitamin C (ascorbyl-6 palmitate) or vitamin E (α-tocopherol acetate), 20% w/w, together with a mixture of concentrated… Expand
Mitochondrial Decay in the Aging Rat Heart
- T. Hagen, R. Moreau, J. Suh, F. Visioli
- Biology
- 1 April 2002
Mitochondrial decay has been postulated to be a significant underlying part of the aging process. Decline in mitochondrial function may lead to cellular energy deficits, especially in times of… Expand
Lipoic acid improves hypertriglyceridemia by stimulating triacylglycerol clearance and downregulating liver triacylglycerol secretion.
Elevated blood triacylglycerol (TG) is a significant contributing factor to the current epidemic of obesity-related health disorders, including type-2 diabetes, nonalcoholic fatty liver disease, and… Expand
Suppression of NLRP3 inflammasome by γ-tocotrienol ameliorates type 2 diabetes[S]
- Yongeun Kim, W. Wang, Meshail Okla, I. Kang, R. Moreau, S. Chung
- Biology, Medicine
- Journal of Lipid Research
- 1 January 2016
The Nod-like receptor 3 (NLRP3) inflammasome is an intracellular sensor that sets off the innate immune system in response to microbial-derived and endogenous metabolic danger signals. We previously… Expand
Dietary supplementation with (R)-α-lipoic acid reverses the age-related accumulation of iron and depletion of antioxidants in the rat cerebral cortex
- J. Suh, R. Moreau, Shi-Hua D Heath, T. Hagen
- Chemistry, Medicine
- Redox report : communications in free radical…
- 1 February 2005
Abstract Accumulation of divalent metal ions (e.g. iron and copper) has been proposed to contribute to heightened oxidative stress evident in aging and neurodegenerative disorders. To understand the… Expand
Characteristics of the rat cardiac sphingolipid pool in two mitochondrial subpopulations.
- Jeffrey S. Monette, L. Gómez, R. Moreau, B. Bemer, Alan W. Taylor, T. Hagen
- Biology, Medicine
- Biochemical and biophysical research…
- 23 July 2010
Mitochondrial sphingolipids play a diverse role in normal cardiac function and diseases, yet a precise quantification of cardiac mitochondrial sphingolipids has never been performed. Therefore, rat… Expand
La formation des équipes d'entrepreneurs
- R. Moreau
- Political Science
- 1 June 2006
Sur quels principes se fondent les associations entre les membres d’une equipe d’entrepreneurs ? Partant de cette question, le present article commence par expliquer ce qu’est l’entrepreneuriat… Expand
Mitochondrial decay in the aging rat heart: evidence for improvement by dietary supplementation with acetyl-L-carnitine and/or lipoic acid.
- T. Hagen, R. Moreau, J. Suh, F. Visioli
- Medicine
- Annals of the New York Academy of Sciences
- 2002
Mitochondrial decay has been postulated to be a significant underlying part of the aging process. Decline in mitochondrial function may lead to cellular energy deficits, especially in times of… Expand