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Pregabalin for acute and chronic pain in adults.
TLDR
Efficacy was demonstrated for dichotomous outcomes equating to moderate or substantial pain relief, alongside lower rates for lack of efficacy discontinuations with increasing dose, in patients with postherpetic neuralgia and painful diabetic neuropathy.
Cannabinoids for control of chemotherapy induced nausea and vomiting: quantitative systematic review
TLDR
The cannabinoids tested in these trials may be useful as mood enhancing adjuvants for controlling chemotherapy related sickness and potentially serious adverse effects, even when taken short term orally or intramuscularly are likely to limit their widespread use.
Physical activity and exercise for chronic pain in adults: an overview of Cochrane Reviews
TLDR
The quality of evidence was low due to participant numbers, length of intervention and follow‐up, and the evidence for any adverse effects or harm associated with physical activity and exercise interventions, though even these statistically significant results had only small‐to‐moderate effect sizes.
Pharmacotherapy for the prevention of chronic pain after surgery in adults.
TLDR
Meta-analysis suggested a modest but statistically significant reduction in the incidence of chronic pain after surgery following treatment with ketamine but not gabapentin or pregabalin, and available evidence does not support the efficacy of gabAPentin, pregABalin, non-steroidal anti-inflammatories, intravenous steroids, oral NMDA blockers or inhaled nitrous oxide for the prevention of chronic postoperative pain.
Efficacy, Dose‐Response, and Safety of Ondansetron in Prevention of Postoperative Nausea and Vomiting: A Quantitative Systematic Review of Randomized Placebo‐controlled Trials
TLDR
If the risk of PONV is very high, for every 100 patients receiving an adequate dose of ondansetron 20 patients will not vomit and three will have a headache who would not have had these adverse effects without the drug.
An Evidence-Based Resource for Pain Relief
TLDR
A single patient data meta-analysis of 3,453 postoperative patients: oral tramadol versus placebo, codeine, and combination analgesics shows significant differences in pain relief from intra-articular morphine after knee surgery.
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