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Palytoxin: A New Marine Toxin from a Coelenterate
Palytoxin has been isolated from the zoanthids "limu-make-o-Hana" (Tentatively identified as Palythoa sp.) as a noncrystalline, chromatographically pure entity and is the most highly toxic substance known.
Siderophore-Iron Uptake in Saccharomyces cerevisiae
A family of four putative transporters in Saccharomyces cerevisiae is expressed under conditions of iron deprivation and is regulated by Aft1p, the major iron-dependent transcription factor in yeast, and it is reported that ARN family members facilitated the uptake of iron from the trihydroxamate siderophores ferrichrome, ferRichrome A, and triacetylfusarinine C.
Toxicity and partial structure of a hepatotoxic peptide produced by the cyanobacterium Nodularia spumigena Mertens emend. L575 from New Zealand
A clonal isolate of the filamentous brackish-water cyanobacterium Nodularia spumigena Mertens emend was found to produce a potent hepatotoxic peptide with chemical and toxicological properties similar to those of the hepatot toxic heptapeptides produced by other freshwater planktonic cyanobacteria.
Naming of cyclic heptapeptide toxins of cyanobacteria (blue-green algae).
The Role of the FRE Family of Plasma Membrane Reductases in the Uptake of Siderophore-Iron in Saccharomyces cerevisiae *
It is proposed that Fre3p and Fre4p are siderophore-iron reductases and that the apparent redundancy of the FRE genes confers the capacity to utilize iron from a variety of sidersophore sources.
Isolation, structure determination, and biological activity of Lyngbyabellin A from the marine cyanobacterium lyngbya majuscula.
The isolation of 1 from L. majuscula once more supports the proposal that many compounds originally isolated from the sea hare Dolabella auricularia are of cyanobacterial origin and was shown to be a potent disrupter of the cellular microfilament network.
Isolation of dolastatin 10 from the marine cyanobacterium Symploca species VP642 and total stereochemistry and biological evaluation of its analogue symplostatin 1.
The potent antitumor agent dolastatin 10 (1) was originally isolated from the sea hare Dolabella auricularia, and we now report its isolation from the marine cyanobacterium Symploca sp. VP642 from
Cyanobacterial nodularin is a potent inhibitor of type 1 and type 2A protein phosphatases.
In a whole-cell extract of T51B liver cells, nodularin inhibited PP1 and PP2A activity with a potency similar to that seen with their purified catalytic subunits, suggesting this hepatotoxin may prove to be useful as a probe for distinguishing the activity of these protein phosphatases in cell extracts.
Total structure determination of apratoxin A, a potent novel cytotoxin from the marine cyanobacterium Lyngbya majuscula.
Apratoxin A (1), a potent cytotoxin with a novel skeleton, has been isolated from the marine cyanobacterium Lyngbya majuscula Harvey ex Gomont; however, it was only marginally active in vivo against a colon tumor and ineffective against a mammary tumor.