Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent.
- A. Alberts, J. Chen, J. Springer
- Chemistry, BiologyProceedings of the National Academy of Sciences…
- 1 July 1980
It was shown that mevinolin was an orally active cholesterol-lowering agent in the dog and orally administered sodium mevinolinate was an active inhibitor of cholesterol synthesis in an acute assay.
Avermectins, New Family of Potent Anthelmintic Agents: Producing Organism and Fermentation
- R. W. Burg, B. M. Miller, S. Ōmura
- BiologyAntimicrobial Agents and Chemotherapy
- 1 March 1979
The avermectins are a complex of chemically related agents which exhibit extraordinarily potent anthelmintic activity. They are produced by a novel species of actinomycete, NRRL 8165, which we have…
Avermectins, New Family of Potent Anthelmintic Agents: Isolation and Chromatographic Properties
- T. Miller, Louis Chaiet, Irving Putter
- Medicine, ChemistryAntimicrobial Agents and Chemotherapy
- 1 March 1979
The avermectins, a family of new anthelmintic agents, were isolated from the mycelia of Streptomyces avermitilis. Four closely related major components and four homologous minor components were…
L-671,329, a new antifungal agent. I. Fermentation and isolation.
- R. Schwartz, R. Giacobbe, J. Bland, R. Monaghan
- BiologyJournal of antibiotics (Tokyo. )
- 25 February 1989
A new lipopeptide antifungal agent, similar to echinocandin B, has been isolated from Zalerion arboricola and studies indicate that L-671,329 is produced under both solid and liquid fermentation conditions.
Difficidin and oxydifficidin: novel broad spectrum antibacterial antibiotics produced by Bacillus subtilis. I. Production, taxonomy and antibacterial activity.
- S. Zimmerman, C. Schwartz, E. Tejera
- BiologyJournal of antibiotics (Tokyo. )
- 25 December 1987
Two novel macrocyclic polyene lactone phosphate esters were discovered in fermentation broths of each of two strains of Bacillus subtilis and each showed a broad spectrum of activity against aerobic and anaerobic bacteria.
Chitosanase, a novel enzyme.
- R. Monaghan, D. Eveleigh, R. Tewari, E. Reese
- BiologyNature: New biology
- 19 September 1973
It is shown that egg white lysozyme will not attack this naturally occurring de-N-acetylated mucopeptide, and other modifications of the chitin polymer exist as essential components of bacterial cell walls.
Improvement in the titer of echinocandin-type antibiotics: A magnesium-limited medium supporting the biphasic production of pneumocandins A0 and B0
- J. Tkacz, R. Giacobbe, R. Monaghan
- BiologyJournal of Industrial Microbiology
- 1 February 1993
A liquid fermentation medium for the submerged culture of the fungus, Zalerion arboricola, which supports the rapid production of an echinocandin-type antibiotic, pneumocand in A0 (formerly L-671, 329), in yields increased at least 4-fold over those reported previously.
A potent nonpeptide cholecystokinin antagonist selective for peripheral tissues isolated from Aspergillus alliaceus.
- R. Chang, V. Lotti, O. Hensens
- BiologyScience
- 11 October 1985
A new, competitive, nonpeptide cholecystokinin (CCK) antagonist, asperlicin, was isolated from the fungus Aspergillus alliaceus. The compound has 300 to 400 times the affinity for pancreatic, ileal,…
Epithienamycins-novel beta-lactams related to thienamycin. I. Production and antibacterial activity.
- E. Stapley, P. Cassidy, D. Hendlin
- Chemistry, BiologyJournal of antibiotics (Tokyo. )
- 1 June 1981
Six major epithienamycin components, and xanthomycin, have been isolated from fermentation broth, and all six components show activity in vitro versus a broad spectrum of bacterial species.
Discovery of novel secondary metabolites from fungi—is it really a random walk through a random forest?
- R. Monaghan, J. Polishook, V. Pecore, G. Bills, M. Nallin-Omstead, S. Streicher
- Biology
- 31 December 1995
Twenty-nine Nodulisporium strains isolated from material obtained worldwide were found to produce secondary metabolites as measured by HPLC, and within the set of cultures that produced the mean or greater than the mean number of metabolites, were found all of the producers of rarer metabolites.
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