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The Drosophila Metabotropic Glutamate Receptor DmGluRA Regulates Activity-Dependent Synaptic Facilitation and Fine Synaptic Morphology
In vertebrates, several groups of metabotropic glutamate receptors (mGluRs) are known to modulate synaptic properties. In contrast, the Drosophila genome encodes a single functional mGluR (DmGluRA),Expand
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Synaptotagmin Interaction with SNAP-25 Governs Vesicle Docking, Priming, and Fusion Triggering
SNARE complex assembly constitutes a key step in exocytosis that is rendered Ca2+-dependent by interactions with synaptotagmin-1. Two putative sites for synaptotagmin binding have recently beenExpand
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The SNAP-25 linker as an adaptation toward fast exocytosis.
The assembly of four soluble N-ethylmaleimide-sensitive factor attachment protein receptor domains into a complex is essential for membrane fusion. In most cases, the four SNARE-domains are encodedExpand
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Membrane-Proximal Tryptophans of Synaptobrevin II Stabilize Priming of Secretory Vesicles
Trans-soluble N-ethylmaleimide-sensitive factor attachment protein (SNAP) receptor (SNARE) complexes formed between the SNARE motifs of synaptobrevin II, SNAP-25, and syntaxin play an essential roleExpand
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v-SNARE transmembrane domains function as catalysts for vesicle fusion
Vesicle fusion is mediated by an assembly of SNARE proteins between opposing membranes, but it is unknown whether transmembrane domains (TMDs) of SNARE proteins serve mechanistic functions that goExpand
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Complexins: small but capable
Despite intensive research, it is still unclear how an immediate and profound acceleration of exocytosis is triggered by appropriate Ca2+-stimuli in presynaptic terminals. This is due to the factExpand
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SNARE Requirements En Route to Exocytosis: from Many to Few
Although it has been known for almost two decades that the ternary complex of N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) constitutes the functional unit driving membraneExpand
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v-SNARE function in chromaffin cells
Vesicle fusion is elementary for intracellular trafficking and release of signal molecules, thus providing the basis for diverse forms of intercellular communication like hormonal regulation orExpand
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The SNAP-25 linker supports fusion intermediates by local lipid interactions
SNAP-25 is an essential component of SNARE complexes driving fast Ca2+-dependent exocytosis. Yet, the functional implications of the tandem-like structure of SNAP-25 are unclear. Here, we haveExpand
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Rolling Blackout Is Required for Synaptic Vesicle Exocytosis
Rolling blackout (RBO) is a putative transmembrane lipase required for phospholipase C-dependent phosphatidylinositol 4,5-bisphosphate–diacylglycerol signaling in Drosophila neurons. ConditionalExpand
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