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Cyclic heptapeptides from the Jamaican sponge Stylissa caribica.
Two new cyclic heptapeptides were isolated and characterized from the Jamaican sponge Stylissa caribica, in addition to the known bromopyrrole alkaloids sceptrin, stevensine, and oroidin, which have been evaluated for their antimicrobial, antimalarial, anticancer,anti-HIV-1, anti-Mtb, and antiinflammatory activities. Expand
Pachycladins A-E, prostate cancer invasion and migration inhibitory Eunicellin-based diterpenoids from the red sea soft coral Cladiella pachyclados.
Five new eunicellin diterpenes, pachycladins A-E (1-5), were isolated from the Red Sea soft coral Cladiella pachyclados and exhibited significant anti-invasive activity. Expand
Di-(2-ethylhexyl) Phthalate, a major bioactive metabolite with antimicrobial and cytotoxic activity isolated from River Nile derived fungus Aspergillus awamori
Abstract The main objective of this study is to investigate the still unexplored River Nile habitat since it was found little information on the chemistry and biology of the River Nile derivedExpand
The Marine Sponge-Derived Polyketide Endoperoxide Plakortide F Acid Mediates Its Antifungal Activity by Interfering with Calcium Homeostasis
It is demonstrated that Plakortide F acid mediates its antifungal activity by perturbing Ca2+ homeostasis, thus representing a potentially novel mechanism distinct from that of currently used antIFungal agents. Expand
Natural product diversity from the endophytic fungi of the genus Aspergillus
The isolated secondary metabolites from different endophytic Aspergillus species reported from January 2015 to December 2019 are discussed along with their reported biological activities and structural aspects whenever applicable. Expand
Scalarane sesterterpenes from the Egyptian Red Sea sponge Phyllospongia lamellosa
Biology and HRESIMS-guided screening of the dichloromethane fraction of the marine sponge Phyllospongia lamellosa collected from the Red Sea resulted in the isolation and characterization of five newExpand
Triterpenoidal saponins: bioactive secondary metabolites from Zygophyllum coccineum.
The isolation of nine ursane-type triterpene saponins, including the new one; zygophylloside S (1), together with a known flavonoid glycoside (10) and a sterol glycosides (11) were tested for antifungal activity against several important plant pathogens and for insecticidal activity against two important mosquito species. Expand
Cytotoxic Activity and Metabolic Profiling of Fifteen Euphorbia Species
Results of Principle component analysis (PCA) come in a great accordance with results of biological testing, which emphasized the cytotoxic properties of E. lactea Haw. Expand
Correlation of serum interleukin-10 level with disease activity and severity in systemic lupus erythematosus
Background Systemic lupus erythematosus (SLE, lupus) is a syndrome of multifactorial etiology, characterized by widespread inflammation, most commonly affecting women during the childbearing years.Expand
Bioactive Secondary Metabolites from the Red Sea soft coral Heteroxenia fuscescens
The alcoholic extract of Heteroxenia fuscescens was found to possess antipyretic and anti-inflammatory activity and the 6-hydroxy -α- muurolene will be a good candidate for more derivatisation studies to optimize its activity and selectivity as antimicrobial. Expand