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Synthetic Lethality of PARP Inhibition and Ionizing Radiation is p53-dependent
PARP inhibitors (PARPi) are potentially effective therapeutic agents capable of inducing synthetic lethality in tumors with deficiencies in homologous recombination (HR)-mediated DNA repair such asExpand
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Relationship of ionizing radiation-induced synthetic lethality of PARP inhibition in BRCA1-proficient cancer cells with p53.
e14115Background: PARP inhibitors (PARPi) are potentially effective therapeutic agents capable of inducing synthetic lethality in tumors with deficiencies in homologous recombination (HR)-mediated ...
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