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Potential role of human cytomegalovirus and p53 interaction in coronary restenosis.
TLDR
HCMV infection of cultured SMCs enhanced p53 accumulation, which correlated temporally with IE84 expression, and HCMV, and IE84-mediated inhibition of p53 function, may contribute to the development of restenosis.
Mutations in the p53 gene occur in diverse human tumour types
TLDR
It is suggested that most tumours with allelic deletions of chromosome 17p contain p53 point mutations resulting in amino-acid substitutions, and p53 gene mutations are clustered in four 'hot-spots' which exactly coincide with the four most highly conserved regions of the gene.
Merkel cell carcinoma subgroups by Merkel cell polyomavirus DNA relative abundance and oncogene expression
TLDR
Data suggest that MCC may arise through different oncogenic pathways, including ones independent of pRb and MCPyV, and higher viral abundance tumors tended to be associated with less p53 expression, younger age at diagnosis and longer survival.
p53 mutations in human immortalized epithelial cell lines.
TLDR
Human epithelial cell lines were examined for p53 mutations in exons 4-9 which include the evolutionarily conserved regions and wild type p53 was found in human bronchial, esophageal and hepatic epithelial cells immortalized by SV40 T antigen gene and human renal epithelial Cells immortalization by adenovirus 5.
Elevated frequency and functional activity of a specific germ-line p53 intron mutation in familial breast cancer.
TLDR
A single p53 intron mutation in familial breast cancer patients that is present at elevated frequency and has functional activity is identified and demonstrated prolonged in vitro survival in response to cisplatinum treatment and showed decreased chemotherapy-induced apoptosis.
p53 mutations, ras mutations, and p53-heat shock 70 protein complexes in human lung carcinoma cell lines.
TLDR
The p53 and ras genes were frequently, but not always, mutated in the carcinoma cell lines, consistent with the hypothesis that multiple genetic changes involving both protooncogenes and tumor suppressor genes occur during lung carcinogenesis.
Fc gamma RIIIa and Fc gamma RIIa polymorphisms do not predict response to rituximab in B-cell chronic lymphocytic leukemia.
TLDR
The data suggest that Fc gamma RIIIa polymorphisms are not predictive of response in CLL and that, unlike the case with FL, mechanisms of tumor clearance other than antibody-dependent cellular cytotoxicity may be more important.
Manganese superoxide dismutase (MnSOD) polymorphism, α-tocopherol supplementation and prostate cancer risk in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (Finland)
TLDR
An effect of the MnSOD ala/ala genotype on the development of prostate cancer is suggested, and the observation of a stronger association with high-grade tumors may have prognostic implications that should also be pursued.
Immunological detection of viral large T antigen identifies a subset of Merkel cell carcinoma tumors with higher viral abundance and better clinical outcome
TLDR
Classic MCC viral oncogenesis characterized by abundance of MCPyV is clinically relevant as suggested by Sihto et al,16 who demonstrated that viral abundance in MCC correlates with survival.
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