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Genome-wide analysis of microsatellite repeats in humans: their abundance and density in specific genomic regions
The overall SSR density was comparable in all chromosomes, but the density of different repeats, however, showed significant variation.
Synergistic recognition of an epigenetic DNA element by Pleiohomeotic and a Polycomb core complex.
It is reported that Pleiohomeotic (PHO) and a multiprotein Polycomb core complex (PCC) bind highly cooperatively to PREs and a conserved sequence motif, named PCC-binding element (PBE), which is required for PcG silencing in vivo.
The iab-7 Polycomb Response Element Maps to a Nucleosome-Free Region of Chromatin and Requires Both GAGA and Pleiohomeotic for Silencing Activity
It is shown that HS3 is capable of functioning as a Polycomb-dependent silencer in vivo, inducing pairing- dependent silencing of amini-white reporter and that GAGA and Pho interact with these sequences in vitro and that the consensus binding sites for the two proteins are critical for the silencing activity of theiab-7 PRE in vivo.
The Enhancer-Blocking Activity of the Fab-7 Boundary From the Drosophila Bithorax Complex Requires GAGA-Factor-Binding Sites
It is demonstrated that distinct GAGA sites are required for different enhancer-blocking activities at different stages of development and that the enhancers-blocking activity of the endogenous Fab-7 boundary is sensitive to mutations in the gene encoding the G AGA factor Trithorax-like.
Novel motifs distinguish multiple homologues of Polycomb in vertebrates: expansion and diversification of the epigenetic toolkit
The analysis of the sequence of PC homologues in various organisms shows that PC is an ancient gene dating back to pre bilaterian origin that has not only been conserved but has also expanded during the evolution of complexity.
Functional diversification of yeast telomere associated protein, Rif1, in higher eukaryotes
- Easwaran Sreesankar, R. Senthilkumar, V. Bharathi, R. Mishra, Krishnaveni Mishra
- BiologyBMC Genomics
- 19 June 2012
Telomeres are maintained by retrotransposons in all Drosophila species and consequently, telomerase and many of the telomere associated protein homologues are absent, including Rap1, which is the binding partner of Rif1.
SARS-CoV-2 genomics: An Indian perspective on sequencing viral variants
- Surabhi Srivastava, S. Banu, Priya Singh, D. T. Sowpati, R. Mishra
- BiologyJournal of biosciences
- 20 February 2021
The past year is reviewed in the context of the phylogenetic analysis of variants isolated over the course of the pandemic in India and the importance of continued sequencing-based surveillance in the country is highlighted.
Efficient and Specific Targeting of Polycomb Group Proteins Requires Cooperative Interaction between Grainyhead and Pleiohomeotic
- András Blastyák, R. Mishra, F. Karch, H. Gyurkovics
- BiologyMolecular and Cellular Biology
- 15 February 2006
It is proposed that the role of DNA binding proteins in Polycomb group-dependent silencing could be described by a model very similar to that of an enhanceosome, wherein the unique arrangement of protein-protein interaction modules exposed by the cooperatively interactingDNA binding proteins provides targeting specificity.
PERF: an exhaustive algorithm for ultra‐fast and efficient identification of microsatellites from large DNA sequences
A novel algorithm called PERF is presented for extremely fast and comprehensive identification of microsatellites from DNA sequences of any size and provides a clean and flexible command‐line interface to change the default settings, and produces output in an easily‐parseable tab‐ separated format.
Triplet repeats in human genome: distribution and their association with genes and other genomic regions
Analysis of triplet repeats in the complete human genome from the publicly available sequences revealed that AGC and CCG repeat were predominantly present in the coding regions of the genome while UTRs and the upstream sequences contained CCG repeats in relative abundance.