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Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma.
- R. Stupp, W. Mason, +16 authors R. Mirimanoff
- The New England journal of medicine
- 10 March 2005
BACKGROUND Glioblastoma, the most common primary brain tumor in adults, is usually rapidly fatal. The current standard of care for newly diagnosed glioblastoma is surgical resection to the extent… Expand
MGMT gene silencing and benefit from temozolomide in glioblastoma.
BACKGROUND Epigenetic silencing of the MGMT (O6-methylguanine-DNA methyltransferase) DNA-repair gene by promoter methylation compromises DNA repair and has been associated with longer survival in… Expand
Promising survival for patients with newly diagnosed glioblastoma multiforme treated with concomitant radiation plus temozolomide followed by adjuvant temozolomide.
- R. Stupp, P. Dietrich, +12 authors S. Leyvraz
- Journal of clinical oncology : official journal…
- 1 March 2002
PURPOSE Temozolomide is a novel oral alkylating agent with demonstrated efficacy as second-line therapy for patients with recurrent anaplastic astrocytoma and glioblastoma multiforme (GBM). This… Expand
Improved survival in patients with locally advanced prostate cancer treated with radiotherapy and goserelin.
BACKGROUND We conducted a randomized, prospective trial comparing external irradiation with external irradiation plus goserelin (an agonist analogue of gonadotropin-releasing hormone that reduces… Expand
Nomograms for predicting survival of patients with newly diagnosed glioblastoma: prognostic factor analysis of EORTC and NCIC trial 26981-22981/CE.3.
BACKGROUND A randomised trial published by the European Organisation for Research and Treatment of Cancer (EORTC) and the National Cancer Institute of Canada (NCIC) Clinical Trials Group (trial… Expand
Meningioma: analysis of recurrence and progression following neurosurgical resection.
The rates of survival, tumor recurrence, and tumor progression were analyzed in 225 patients with meningioma who underwent surgery as the only treatment modality between 1962 and 1980. Patients were… Expand
CD4 and CD8 T-Lymphocyte Apoptosis Can Predict Radiation-Induced Late Toxicity: A Prospective Study in 399 Patients
- M. Ozsahin, N. E. Crompton, +7 authors D. Azria
- Medicine, Biology
- Clinical Cancer Research
- 15 October 2005
Purpose: Predicting late effects in patients treated with radiation therapy by assessing in vitro radiation-induced CD4 and CD8 T-lymphocyte apoptosis can be useful in individualizing treatment.… Expand
Clinical implications of the p53 tumor-suppressor gene.
Health-related quality of life in patients with glioblastoma: a randomised controlled trial.
BACKGROUND A randomised controlled trial of radiotherapy alone versus radiotherapy with concomitant and adjuvant temozolomide for patients with glioblastoma showed that survival was higher for… Expand
Changing paradigms--an update on the multidisciplinary management of malignant glioma.
Treatment of malignant glioma requires a multidisciplinary team. Treatment includes surgery, radiotherapy, and chemotherapy. Recently developed agents have demonstrated activity against recurrent… Expand