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Ionizing radiation-induced, mitochondria-dependent generation of reactive oxygen/nitrogen.
TLDR
Measurements of radiation-induced mitogen-activated protein kinase activity indicate that this sensing/amplification mechanism is necessary for activation of some cytoplasmic signaling pathways by low doses of radiation. Expand
Biological chemistry of reactive oxygen and nitrogen and radiation-induced signal transduction mechanisms
TLDR
It is proposed that radiation-induced ROS are the initiators and that nitric oxide (NO•) or derivatives are the effectors activating these signal transduction pathways and the cell converts an oxidative signal to a nitrosative one in responding to cellular ionization events. Expand
Radiation-induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation
TLDR
It is proposed that accelerated repopulation of tumors whose growth is regulated by EGFR is initiated by an IR-induced EGFR activation mechanism that mimics the effects of growth factors. Expand
Signal Transduction and Cellular Radiation Responses
TLDR
There is increasing evidence for the functional links between cellular signal transduction responses and DNA damage recognition and repair, cell survival, or cell death through apoptosis or reproductive mechanisms. Expand
The relative role of ErbB1–4 receptor tyrosine kinases in radiation signal transduction responses of human carcinoma cells
TLDR
ErbB2 is a modulator of ErbB1 (or 4) function leading to different MAPK response profiles to GF or radiation exposure, which is similar to that of GFs or radiation. Expand
Ionizing radiation activates Erb-B receptor dependent Akt and p70 S6 kinase signaling in carcinoma cells
TLDR
It is demonstrated that the Erb-B receptor tyrosine kinase network stimulates cytoprotective p70 S6 kinase and Akt activity in response to clinically relevant doses of ionizing radiation. Expand
The mitogen-activated protein (MAP) kinase cascade can either stimulate or inhibit DNA synthesis in primary cultures of rat hepatocytes depending upon whether its activation is acute/phasic or
TLDR
Data suggest a general mechanism exists where acute activation of the MAP kinase cascade promotes G1 progression/S phase entry and that chronic activation ofThe MAP Kinase cascade inhibits this process, and demonstrate that NGF can cause either acute/phasic or sustained activation ofthe MAP kinases cascade in different cell types. Expand
Activation of Constitutive Nitric-oxide Synthase Activity Is an Early Signaling Event Induced by Ionizing Radiation*
TLDR
These experiments establish NO-dependent signal transduction pathways as being radioresponsive and suggest a possible mechanism by which ionization events in one cell may activate signaling processes in adjacent cells. Expand
Physical Activity and Sedentary Behavior of Cancer Survivors and Non-Cancer Individuals: Results from a National Survey
TLDR
It is suggested that cancer survivors tend to have more physical activity, but they are also more likely to engage in sedentary behavior, compared to non-cancer participants. Expand
Dominant-negative cAMP-responsive Element-binding Protein Inhibits Proliferating Cell Nuclear Antigen and DNA Repair, Leading to Increased Cellular Radiosensitivity*
TLDR
Data demonstrate that genetic disruption of CREB results in radiosensitization, and that this effect can be explained by a mechanism involving decreased PCNA expression and inhibition of DNA repair. Expand
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