• Publications
  • Influence
Characterization of the chromosomal aac(6')-Ic gene from Serratia marcescens
High-pressure liquid chromatographic analysis of extracts prepared from Escherichia coli carrying the chromosomal aac(6')-Ic gene on a plasmid confirmed the presence of 6'-N-acetyltransferase activity in this strain, which was suggested by the aminoglycoside resistance profile.
Verongamine, a novel bromotyrosine-derived histamine H3-antagonist from the marine sponge Verongula gigantea.
The novel bromotyrosine derivative verongamine has been isolated from the marine sponge Verongula gigantea and is a specific histamine-H3 antagonist at concentrations as low as 1 microgram/ml.
Chemokine receptor CCR-5 inhibitors produced by Chaetomium globosum.
Two novel chemokine receptor CCR-5 inhibitors were isolated from the fungal fermentation broth of Chaetomium globosum by normal- and reversed-phase HPLC purifications and the structure and relative configuration of 2 were determined unequivocally by X-ray crystallographic analysis.
Isolation, characterization, and DNA sequence analysis of an AAC(6')-II gene from Pseudomonas aeruginosa
It is speculated that these two genes arose from a common ancestor and that the processes of selection and dissemination have led to the observed differences in the spectrum of aminoglycoside resistance.
Sch 54445: a new polycyclic xanthone with highly potent antifungal activity produced by Actinoplanes sp.
As a broad-spectrum antifungal agent, Sch 54445 exhibits highly potent activities against various yeasts and dermatophytes with MIC values approximately 0.00038 microgram/mL.
Isolation and structure elucidation of Sch 642305, a novel bacterial DNA primase inhibitor produced by Penicillium verrucosum.
A novel primase inhibitor, Sch 642305 (1), was isolated from the fermentation broth of the fungal culture Penicillium verrucosum and exhibited inhibitory activity against bacterial DNA primase enzyme with an EC(50) of 70 microM.
A new sterol sulfate, Sch 572423, from a marine sponge, Topsentia sp.
Bioassay-guided fractionation of an active fraction from a marine sponge Topsentia sp. in our marine fraction library (MFL) led to the isolation and identification of halistanol sulfate (1) and a new
Two novel diketopiperazines isolated from the fungus Tolypocladium sp.
Abstract Diketopiperazines, Sch 54794 and Sch 54796, have been isolated from a fungal fermentation. The structures of these compounds have been established based on spectroscopic data analysis. Sch
Analysis of the aac(3)-VIa gene encoding a novel 3-N-acetyltransferase
Primer extension analysis has identified a promoter for the aac(3)-VIa gene downstream of both the aadA1 gene and a 59-base element often seen in an integron environment.
Photodiode array detection of peptide-nucleoside antibiotics.
From the combined HPLC-PDA evaluation of the fermentation filtrate from culture broth 83-2245, two blasticidin S type compounds could be detected and fast atom bombardment mass spectroscopic evaluations and mass-analysed ion kinetic energy spectra of these nucleosides confirmed their respective identities.