Analysis of the aac(3)-VIa gene encoding a novel 3-N-acetyltransferase
- P. Rather, P. Mann, R. Mierzwa, R. Hare, G. Miller, K. Shaw
- BiologyAntimicrobial Agents and Chemotherapy
- 1 October 1993
Primer extension analysis has identified a promoter for the aac(3)-VIa gene downstream of both the aadA1 gene and a 59-base element often seen in an integron environment.
Characterization of the chromosomal aac(6')-Ic gene from Serratia marcescens
High-pressure liquid chromatographic analysis of extracts prepared from Escherichia coli carrying the chromosomal aac(6')-Ic gene on a plasmid confirmed the presence of 6'-N-acetyltransferase activity in this strain, which was suggested by the aminoglycoside resistance profile.
Chemokine receptor CCR-5 inhibitors produced by Chaetomium globosum.
Two novel chemokine receptor CCR-5 inhibitors were isolated from the fungal fermentation broth of Chaetomium globosum by normal- and reversed-phase HPLC purifications and the structure and relative configuration of 2 were determined unequivocally by X-ray crystallographic analysis.
Verongamine, a novel bromotyrosine-derived histamine H3-antagonist from the marine sponge Verongula gigantea.
The novel bromotyrosine derivative verongamine has been isolated from the marine sponge Verongula gigantea and is a specific histamine-H3 antagonist at concentrations as low as 1 microgram/ml.
Two novel diketopiperazines isolated from the fungus Tolypocladium sp.
Isolation, characterization, and DNA sequence analysis of an AAC(6')-II gene from Pseudomonas aeruginosa
It is speculated that these two genes arose from a common ancestor and that the processes of selection and dissemination have led to the observed differences in the spectrum of aminoglycoside resistance.
Isolation and structure elucidation of Sch 642305, a novel bacterial DNA primase inhibitor produced by Penicillium verrucosum.
A novel primase inhibitor, Sch 642305 (1), was isolated from the fermentation broth of the fungal culture Penicillium verrucosum and exhibited inhibitory activity against bacterial DNA primase enzyme with an EC(50) of 70 microM.
A new sterol sulfate, Sch 572423, from a marine sponge, Topsentia sp.
Sch 54445: a new polycyclic xanthone with highly potent antifungal activity produced by Actinoplanes sp.
As a broad-spectrum antifungal agent, Sch 54445 exhibits highly potent activities against various yeasts and dermatophytes with MIC values approximately 0.00038 microgram/mL.