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Paracrine interactions of basic fibroblast growth factor and interleukin-6 in multiple myeloma.
Myeloma cells express basic fibroblast growth factor (bFGF), an angiogenic cytokine triggering marrow neovascularization in multiple myeloma (MM). In solid tumors and some lymphohematopoietic… Expand
S100A2 Induces Metastasis in Non–Small Cell Lung Cancer
- Etmar Bulk, B. Sargin, +14 authors C. Müller-Tidow
- Biology, Medicine
- Clinical Cancer Research
- 1 January 2009
Purpose: S100 proteins are implicated in metastasis development in several cancers. In this study, we analyzed the prognostic role of mRNA levels of all S100 proteins in early stage non–small cell… Expand
Impact of Thrombophilia on Risk of Arterial Ischemic Stroke or Cerebral Sinovenous Thrombosis in Neonates and Children: A Systematic Review and Meta-Analysis of Observational Studies
Background— The aim of this study was to estimate the impact of thrombophilia on risk of first childhood stroke through a meta-analysis of published observational studies. Methods and Results— A… Expand
A phase 2 clinical study of SU5416 in patients with refractory acute myeloid leukemia.
Neoangiogenesis has been shown to play an important role in the pathogenesis of acute myeloid leukemia (AML). Autocrine and paracrine secretion of angiogenic and hematopoietic growth factors such as… Expand
Randomized study to evaluate the use of high-dose therapy as part of primary treatment for "aggressive" lymphoma.
- U. Kaiser, I. Uebelacker, +26 authors K. Havemann
- Journal of clinical oncology : official journal…
- 15 November 2002
PURPOSE This trial of the German High-Grade Non-Hodgkin's Lymphoma Study Group compares the use of high-dose therapy (HDT) as part of primary treatment with cyclophosphamide, doxorubicin,… Expand
Dilemmas in the management of atrial fibrillation in chronic kidney disease.
- H. Reinecke, E. Brand, +4 authors G. Breithardt
- Journal of the American Society of Nephrology…
- 1 April 2009
Patients with chronic kidney disease (CKD) have an increased risk for cardiovascular morbidity and mortality. Little attention has been paid to the problem of atrial fibrillation, although this… Expand
Binding of protein S to factor Va associated with inhibition of prothrombinase that is independent of activated protein C.
- M. Heeb, R. Mesters, G. Tans, J. Rosing, J. Griffin
- Chemistry, Medicine
- The Journal of biological chemistry
- 5 February 1993
Since plasma protein S serves an anticoagulant function by mechanisms which are not completely understood, its possible interaction with Factor Va was investigated. Human protein S bound to… Expand
Nanoparticles that communicate in vivo to amplify tumour targeting.
- G. von Maltzahn, J. Park, +7 authors S. Bhatia
- Chemistry, Computer Science
- Nature materials
- 1 June 2011
Communicating nanoparticle systems can be composed of multiple types of signalling and receiving modules, can transmit information through multiple molecular pathways in coagulation, can operate autonomously and can target over 40 times higher doses of chemotherapeutics to tumours than non-communicating controls. Expand
Expression of angiopoietins and their receptor Tie2 in the bone marrow of patients with acute myeloid leukemia.
BACKGROUND AND OBJECTIVES Angiopoietin-1 (Ang-1) and its natural antagonist angiopoietin-2 (Ang-2), both ligands for the receptor tyrosine kinase Tie2, are known to play an essential role in normal… Expand
A phase 2 pilot study of pegfilgrastim and filgrastim for mobilizing peripheral blood progenitor cells in patients with non-Hodgkin’s lymphoma receiving chemotherapy
This phase 2 randomized, double-blind trial examines the efficacy of pegfilgrastim and filgrastim for mobilizing peripheral blood progenitors cells following chemotherapy in patients with… Expand