Increased Neurogenesis in the Dentate Gyrus After Transient Global Ischemia in Gerbils
- Jialing Liu, Karen Solway, R. Messing, F. Sharp
- BiologyJournal of Neuroscience
- 1 October 1998
Neurogenesis in the dentate gyrus of adult rodents is regulated by NMDA receptors, adrenal steroids, environmental stimuli, and seizures. To determine whether ischemia affects neurogenesis, newly…
The type 1 equilibrative nucleoside transporter regulates ethanol intoxication and preference
- D. Choi, M. Cascini, R. Messing
- Medicine, BiologyNature Neuroscience
- 1 August 2004
It is reported that ENT1-null mice show reduced hypnotic and ataxic responses to ethanol and greater consumption of alcohol as compared with their wild-type littermates and suggested that decreased A1 adenosine receptor function promotes alcohol consumption.
Protein kinase C isozymes and the regulation of diverse cell responses.
- E. Dempsey, A. Newton, R. Messing
- Biology, ChemistryAmerican Journal of Physiology - Lung cellular…
- 1 September 2000
New ideas on mechanisms that regulate PKC activity, including the identification of a novel PKC kinase, 3-phosphoinositide-dependent kinase-1 (PDK-1), that regulates phosphorylation of PKC, have been advanced and opposing roles for selected isozymes in the same cell system have been defined.
Prkcz null mice show normal learning and memory
- A. Lee, B. Kanter, R. Messing
- Biology, PsychologyNature
- 26 November 2012
It is shown that absence of PKM-ζ does not impair learning and memory in mice, and that ZIP can erase reward memory even when PKM -ζ is not present.
A novel nociceptor signaling pathway revealed in protein kinase C epsilon mutant mice.
- S. Khasar, Y. Lin, R. Messing
- BiologyNeuron
- 1999
It is shown that epinephrine-induced mechanical and thermal hyperalgesia and acetic acid-associated hyperalGESia are markedly attenuated in PKCepsilon mutant mice, but baseline nociceptor thresholds are normal, indicating that PKCEPsilon regulates nocICEptor function and suggesting thatPKCep silon inhibitors could prove useful in the treatment of pain.
A Novel Nociceptor Signaling Pathway Revealed in Protein Kinase C ε Mutant Mice
- S. Khasar, Yu-Huei Lin, R. Messing
- BiologyNeuron
- 1 September 1999
A Transgenic Rat for Investigating the Anatomy and Function of Corticotrophin Releasing Factor Circuits
- M. Pomrenze, E. Z. Millan, R. Messing
- BiologyFrontiers in Neuroscience
- 24 December 2015
Results indicate that CeL CRF neurons provide both local inhibitory GABA and excitatory CRF signals to other CeA neurons, and demonstrate the value of the Crh-Cre rat as a tool for studying circuit function and physiology ofCRF neurons.
Cortical activation of accumbens hyperpolarization-active NMDARs mediates aversion-resistant alcohol intake
- T. Seif, Shao-Ju Chang, F. Hopf
- Biology, MedicineNature Neuroscience
- 1 August 2013
It is shown that nucleus accumbens core (NAcore) NMDA-type glutamate receptors and medial prefrontal (mPFC) and insula glutamatergic inputs to the NAcore are necessary for aversion-resistant alcohol consumption in rats.
Chronic Hypersensitivity For Inflammatory Nociceptor Sensitization Mediated by the ε Isozyme of Protein Kinase C
- K. Aley, R. Messing, D. Mochly‐Rosen, J. Levine
- Biology, MedicineJournal of Neuroscience
- 15 June 2000
The findings indicate that different second messenger pathways underlie acute and prolonged inflammatory pain, and the role of PKA or PKG antagonists in this situation is unclear.
A semisynthetic epitope for kinase substrates
- J. Allen, Manqing Li, K. Shokat
- BiologyNature Methods
- 1 June 2007
A semisynthetic reaction scheme is developed, which results in the affinity tagging of substrates of the kinase in question, which allowed purification of a direct Erk2 substrate in cells isolated from a mouse that expressed endogenous levels of an analog-specific kinase (Erk2).
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