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Antiretroviral neurotoxicity
Combination antiretroviral therapy (CART) has proven to effectively suppress systemic HIV burden, however, poor penetration into the central nervous system (CNS) provides incomplete protection.Expand
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An Attenuating Mutation in nsP1 of the Sindbis-Group Virus S.A.AR86 Accelerates Nonstructural Protein Processing and Up-Regulates Viral 26S RNA Synthesis
ABSTRACT The Sindbis-group alphavirus S.A.AR86 encodes a threonine at nonstructural protein 1 (nsP1) 538 that is associated with neurovirulence in adult mice. Mutation of the nsP1 538 Thr to theExpand
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Myo10 in brain: developmental regulation, identification of a headless isoform and dynamics in neurons
Although Myo10 (myosin-X) is an unconventional myosin associated with filopodia, little is known about its isoforms and roles in the nervous system. We report here that, in addition to full-lengthExpand
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Cell trafficking through the choroid plexus
The choroid plexus is a multifunctional organ that sits at the interface between the blood and cerebrospinal fluid (CSF). It serves as a gateway for immune cell trafficking into the CSF and is in anExpand
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Astrocytes and microglia differentially regulate trafficking of lymphocyte subsets across brain endothelial cells
Feline brain endothelial cells (BECs), astrocytes, and microglia were combined in different configurations in a cell culture insert system to assess the effect of different cell types on theExpand
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The neuropathogenesis of feline immunodeficiency virus infection: barriers to overcome.
Feline immunodeficiency virus (FIV), like human immunodeficiency virus (HIV)-1, is a neurotropic lentivirus, and both natural and experimental infections are associated with neuropathology. FIVExpand
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Quantitative mapping of glutamate presynaptic terminals in the supraoptic nucleus and surrounding hypothalamus
Although the hypothalamus is generally regarded to have low levels of glutamate receptors, anatomical and physiological studies have provided consistent evidence implicating glutamate as a potentialExpand
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The p75 neurotrophin receptor: at the crossroad of neural repair and death
The strong repair and pro-survival functions of neurotrophins at their primary receptors, TrkA, TrkB and TrkC, have made them attractive candidates for treatment of nervous system injury and disease.Expand
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Protein changes in CSF of HIV-infected patients: evidence for loss of neuroprotection
To begin to unravel the complexity of HIV-associated changes in the brain, broader, multifaceted analyses of cerebrospinal fluid (CSF) are needed that examine a wide range of proteins reflectingExpand
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Glutamate receptors in the rat hypothalamus and pituitary.
Although several recent anatomical and physiological studies indicate that glutamate receptors are likely to play a role in the regulation of various hypothalamic functions, no attempt has yet beenExpand
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