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Antiretroviral neurotoxicity
The current studies evaluated the direct effects of 15 antiretroviral compounds on neurons to begin to provide basic neurotoxicity data that will serve as a foundation for the development of dosing and drug selection guidelines. Expand
Cell trafficking through the choroid plexus
The choroid plexus is a multifunctional organ that sits at the interface between the blood and cerebrospinal fluid and is in an excellent position to provide continuous immune surveillance by CD4+ T cells, macrophages and dendritic cells and to regulate immune cell trafficking in response to disease and trauma. Expand
Astrocytes and microglia differentially regulate trafficking of lymphocyte subsets across brain endothelial cells
Interaction between the triad of endothelial cells, astrocytes, and microglia played an important, but varying, role in the trafficking of different PBMC subsets, with astroCytes having a positive effect on trafficking of PBMCs, whilemicroglia had a suppressive effect. Expand
Quantitative mapping of glutamate presynaptic terminals in the supraoptic nucleus and surrounding hypothalamus
Results suggest that glutamate is the predominant excitatory transmitter used for control of vasopressin/oxytocin cells and the relative contribution of glutamate neurotransmission to a particular region will depend, in part, on the number and type of competing non-glutamate terminals. Expand
Myo10 in brain: developmental regulation, identification of a headless isoform and dynamics in neurons
It is reported here that, in addition to full-length Myo10, brain expresses a shorter form of MyO10 that lacks a myosin head domain, which is unable to function as a molecular motor and, like it, contains three pleckstrin homology (PH) domains. Expand
An Attenuating Mutation in nsP1 of the Sindbis-Group Virus S.A.AR86 Accelerates Nonstructural Protein Processing and Up-Regulates Viral 26S RNA Synthesis
Results suggest that slower nonstructural protein processing and delayed 26S RNA synthesis in wild-type S.A.AR86 infections may contribute to the adult mouse neurovirulence phenotype of S. a.AR 86. Expand
The neuropathogenesis of feline immunodeficiency virus infection: barriers to overcome.
In this review the results of both in vitro and in vivo FIV studies are assessed in an attempt to elucidate the mechanisms of viral entry into the brain. Expand
Glutamate receptors in the rat hypothalamus and pituitary.
Although several recent anatomical and physiological studies indicate that glutamate receptors are likely to play a role in the regulation of various hypothalamic functions, no attempt has yet beenExpand
The p75 neurotrophin receptor: at the crossroad of neural repair and death
A great deal remains to be discovered about the wide ranging functions of the p75 NTR, but studies summarized in this review highlight the immense potential for development of novel neuroprotective and neurorestorative therapies. Expand
Protein changes in CSF of HIV-infected patients: evidence for loss of neuroprotection
It is illustrated that HIV infection is associated with parallel changes in both inflammatory and neuroprotective proteins in the CSF, and the inverse relationship between growth factors and neurological disease severity suggests that a loss of growth factor neuroprotection may contribute to the development of neural damage and may provide useful markers of disease progression. Expand