A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
- R. Medzhitov, P. Preston-Hurlburt, C. Janeway
- BiologyNature
- 24 July 1997
The cloning and characterization of a human homologue of the Drosophila toll protein (Toll) is reported, which has been shown to induce the innate immune response in adult Dosophila.
Origin and physiological roles of inflammation
- R. Medzhitov
- BiologyNature
- 1 July 2008
This work has shown that tissue stress or malfunction induces an adaptive response that is intermediate between the basal homeostatic state and a classic inflammatory response, which is referred to here as para-inflammation.
Innate immune recognition.
- C. Janeway, R. Medzhitov
- BiologyAnnual Review of Immunology
- 2002
Microbial recognition by Toll-like receptors helps to direct adaptive immune responses to antigens derived from microbial pathogens to distinguish infectious nonself from noninfectious self.
Toll-like receptor control of the adaptive immune responses
- A. Iwasaki, R. Medzhitov
- BiologyNature Immunology
- 1 October 2004
Recognition of microbial infection and initiation of host defense responses is controlled by multiple mechanisms and recent studies have provided important clues about the mechanisms of TLR-mediated control of adaptive immunity orchestrated by dendritic cell populations in distinct anatomical locations.
Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
- L. Alexopoulou, Agnieszka Czopik Holt, R. Medzhitov, R. Flavell
- BiologyNature
- 18 October 2001
It is shown that mammalian TLR3 recognizes dsRNA, and that activation of the receptor induces the activation of NF-κB and the production of type I interferons (IFNs).
Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis
- S. Rakoff-Nahoum, J. Paglino, Fatima Eslami-Varzaneh, S. Edberg, R. Medzhitov
- BiologyCell
- 23 July 2004
Recognition of microorganisms and activation of the immune response
- R. Medzhitov
- BiologyNature
- 17 October 2007
The mammalian immune system has innate and adaptive components, which cooperate to protect the host against microbial infections, and recent progress brings us closer to an integrated view of the immune system and its function in host defence.
Toll-like receptors and innate immunity
- R. Medzhitov
- BiologyNature reviews. Immunology
- 1 November 2001
This work has shown that activation of inflammatory and antimicrobial innate immune responses through recognition of Toll-like receptors expressed on dendritic cells triggers functional maturation of dendrites and leads to initiation of antigen-specific adaptive immune responses.
Toll-like Receptor 9–mediated Recognition of Herpes Simplex Virus-2 by Plasmacytoid Dendritic Cells
- Jennifer M. Lund, A. Sato, S. Akira, R. Medzhitov, A. Iwasaki
- BiologyJournal of Experimental Medicine
- 4 August 2003
A novel mechanism whereby the genomic DNA of a virus can engage TLR9 and result in the secretion of IFN-α by pDCs is demonstrated.
MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways.
- R. Medzhitov, P. Preston-Hurlburt, C. Janeway
- BiologyMolecules and Cells
- 1 August 1998
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