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Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells.
TLDR
A molecular linkage between an antioxidant sensitive transcriptional regulatory mechanism and VCAM-1 gene expression is suggested that expands on the notion of oxidative stress as an important regulatory signal in the pathogenesis of atherosclerosis. Expand
Oxidative stress as a regulator of gene expression in the vasculature.
TLDR
The evidence supporting the notion that oxidative stress and the production of ROS function as physiological regulators of vascular gene expression mediated via specific redox-sensitive signal transduction pathways and transcriptional regulatory networks is summarized. Expand
Hyperglycemia-induced activation of nuclear transcription factor kappaB in vascular smooth muscle cells.
TLDR
The results suggest that hyperglycemia-induced activation of NF-kappaB in VSMCs may be a key mechanism for the accelerated vascular disease observed in diabetes. Expand
Nitric oxide regulates vascular cell adhesion molecule 1 gene expression and redox-sensitive transcriptional events in human vascular endothelial cells.
TLDR
DETA-NO modifies the reactivity of oxygen intermediates in the vascular endothelium and may function as an immunomodulator of the vessel wall and thus mediate inflammatory events involved in the pathogenesis of atherosclerosis. Expand
Oscillatory shear stress stimulates adhesion molecule expression in cultured human endothelium.
TLDR
It is shown here that prolonged oscillatory shear stress induces expression of endothelial cell leukocytes adhesion molecules, which are centrally important in mediating leukocyte localization into the arterial wall, and that the mechanism of upregulation is, to some extent, redox sensitive. Expand
Laminar Flow Induction of Antioxidant Response Element-mediated Genes in Endothelial Cells
TLDR
The ARE is defined as a novel endothelial shear stress response element and laminar flow activation of antioxidant genes via an ARE-dependent transcriptional mechanism may represent a novel athero-protective and anti-inflammatory mechanism in the vasculature. Expand
Superoxide, H2O2, and iron are required for TNF-alpha-induced MCP-1 gene expression in endothelial cells: role of Rac1 and NADPH oxidase.
TLDR
The data suggest that ROS such as superoxide and H(2)O( 2) derived from Rac1-activated NADPH oxidase mediate TNF-alpha-induced MCP-1 expression in endothelial cells. Expand
Angiotensin II induces vascular cell adhesion molecule-1 expression in rat vasculature: A potential link between the renin-angiotensin system and atherosclerosis.
TLDR
The hypothesis that angiotensin II (Ang II) may contribute to atherosclerosis by increasing expression of vascular inflammatory genes such as vascular cell adhesion molecule-1 (VCAM-1) is tested. Expand
Angiotensin II induces monocyte chemoattractant protein-1 gene expression in rat vascular smooth muscle cells.
TLDR
The effects of angiotensin II (Ang II) on MCP-1 gene expression in rat aortic smooth muscle cells were studied to investigate a potential molecular basis for a link between hypertension and atherosclerosis. Expand
Modified low density lipoprotein and its constituents augment cytokine-activated vascular cell adhesion molecule-1 gene expression in human vascular endothelial cells.
TLDR
As long-term regulatory signals, specific oxidized fatty acid and phospholipid components of oxLDL augment the ability of vascular endothelial cells to express cytokine-mediated VCAM-1, which is involved in early atherosclerosis. Expand
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