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Isolation and structure of a brain constituent that binds to the cannabinoid receptor.
Arachidonylethanolamide, an arachidonic acid derivative in porcine brain, was identified in a screen for endogenous ligands for the cannabinoid receptor. The structure of this compound, which hasExpand
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International Union of Pharmacology. XXVII. Classification of Cannabinoid Receptors
Two types of cannabinoid receptor have been discovered so far, CB1 (2.1: CBD:1:CB1:), cloned in 1990, and CB2(2.1:CBD:2:CB2:), cloned in 1993. Distinction between these receptors is based onExpand
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International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2
There are at least two types of cannabinoid receptors (CB1 and CB2). Ligands activating these G protein-coupled receptors (GPCRs) include the phytocannabinoid Δ9-tetrahydrocannabinol, numerousExpand
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Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide
(−)‐Cannabidiol (CBD) is a non‐psychotropic component of Cannabis with possible therapeutic use as an anti‐inflammatory drug. Little is known on the possible molecular targets of this compound. WeExpand
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Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors.
In this study, we report the isolation from canine intestines of 2-arachidonyl glycerol (2-Ara-Gl). Its structure was determined by mass spectrometry and by direct comparison with a synthetic sample.Expand
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Isolation, Structure, and Partial Synthesis of an Active Constituent of Hashish
strongly solvated than triple ions,lb-5 the difference being greater for cations of smaller radii, leading to a trend to smaller K with decreasing cationic radii. Both effects, in oppositeExpand
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An endogenous cannabinoid (2-AG) is neuroprotective after brain injury
Traumatic brain injury triggers the accumulation of harmful mediators that may lead to secondary damage. Protective mechanisms to attenuate damage are also set in motion. 2-Arachidonoyl glycerolExpand
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Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb.
Delta(9)-tetrahydrocannabinol binds cannabinoid (CB(1) and CB(2)) receptors, which are activated by endogenous compounds (endocannabinoids) and are involved in a wide range of physiopathologicalExpand
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Peripheral cannabinoid receptor, CB2, regulates bone mass.
  • O. Ofek, M. Karsak, +10 authors I. Bab
  • Medicine, Chemistry
  • Proceedings of the National Academy of Sciences…
  • 17 January 2006
The endogenous cannabinoids bind to and activate two G protein-coupled receptors, the predominantly central cannabinoid receptor type 1 (CB1) and peripheral cannabinoid receptor type 2 (CB2). WhereasExpand
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The endocannabinoid system and the brain.
The psychoactive constituent in cannabis, Δ(9)-tetrahydrocannabinol (THC), was isolated in the mid-1960s, but the cannabinoid receptors, CB1 and CB2, and the major endogenous cannabinoids (anandamideExpand
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