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Isolation and structure of a brain constituent that binds to the cannabinoid receptor.
Arachidonylethanolamide, an arachidonic acid derivative in porcine brain, was identified in a screen for endogenous ligands for the cannabinoid receptor. The structure of this compound, which has… Expand
International Union of Pharmacology. XXVII. Classification of Cannabinoid Receptors
Two types of cannabinoid receptor have been discovered so far, CB1 (2.1: CBD:1:CB1:), cloned in 1990, and CB2(2.1:CBD:2:CB2:), cloned in 1993. Distinction between these receptors is based on… Expand
International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2
There are at least two types of cannabinoid receptors (CB1 and CB2). Ligands activating these G protein-coupled receptors (GPCRs) include the phytocannabinoid Δ9-tetrahydrocannabinol, numerous… Expand
Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide
- T. Bisogno, L. Hanuš, +7 authors V. Di Marzo
- Medicine, Chemistry
- British journal of pharmacology
- 1 October 2001
(−)‐Cannabidiol (CBD) is a non‐psychotropic component of Cannabis with possible therapeutic use as an anti‐inflammatory drug. Little is known on the possible molecular targets of this compound. We… Expand
Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors.
- R. Mechoulam, S. Ben-Shabat, +7 authors D. Compton
- Chemistry, Medicine
- Biochemical pharmacology
- 29 June 1995
In this study, we report the isolation from canine intestines of 2-arachidonyl glycerol (2-Ara-Gl). Its structure was determined by mass spectrometry and by direct comparison with a synthetic sample.… Expand
Isolation, Structure, and Partial Synthesis of an Active Constituent of Hashish
strongly solvated than triple ions,lb-5 the difference being greater for cations of smaller radii, leading to a trend to smaller K with decreasing cationic radii. Both effects, in opposite… Expand
An endogenous cannabinoid (2-AG) is neuroprotective after brain injury
Traumatic brain injury triggers the accumulation of harmful mediators that may lead to secondary damage. Protective mechanisms to attenuate damage are also set in motion. 2-Arachidonoyl glycerol… Expand
Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb.
- A. Izzo, F. Borrelli, R. Capasso, V. Di Marzo, R. Mechoulam
- Trends in pharmacological sciences
- 1 October 2009
Delta(9)-tetrahydrocannabinol binds cannabinoid (CB(1) and CB(2)) receptors, which are activated by endogenous compounds (endocannabinoids) and are involved in a wide range of physiopathological… Expand
Peripheral cannabinoid receptor, CB2, regulates bone mass.
- O. Ofek, M. Karsak, +10 authors I. Bab
- Medicine, Chemistry
- Proceedings of the National Academy of Sciences…
- 17 January 2006
The endogenous cannabinoids bind to and activate two G protein-coupled receptors, the predominantly central cannabinoid receptor type 1 (CB1) and peripheral cannabinoid receptor type 2 (CB2). Whereas… Expand
The endocannabinoid system and the brain.
The psychoactive constituent in cannabis, Δ(9)-tetrahydrocannabinol (THC), was isolated in the mid-1960s, but the cannabinoid receptors, CB1 and CB2, and the major endogenous cannabinoids (anandamide… Expand