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Isolation and structure of a brain constituent that binds to the cannabinoid receptor.
Arachidonylethanolamide, an arachidonic acid derivative in porcine brain, was identified in a screen for endogenous ligands for the cannabinoid receptor. The structure of this compound, which has… Expand
International Union of Pharmacology. XXVII. Classification of Cannabinoid Receptors
It is considered premature to rename cannabinoid receptors after an endogenous agonist as is recommended by the International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification, because pharmacological evidence for the existence of additional types of cannabinoid receptor is emerging and other kinds of supporting evidence are still lacking. Expand
International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2
This review summarizes current data indicating the extent to which cannabinoid receptor ligands undergo orthosteric or allosteric interactions with non- CB1, non-CB2 established GPCRs, deorphanized receptors such as GPR55, ligand-gated ion channels, transient receptor potential (TRP) channels, and other ion channels or peroxisome proliferator-activated nuclear receptors. Expand
Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide
- T. Bisogno, L. Hanuš, +7 authors V. Di Marzo
- Chemistry, Medicine
- British journal of pharmacology
- 1 October 2001
Results suggest that VR1 receptors, or increased levels of endogenous AEA, might mediate some of the pharmacological effects of CBD and its analogues, and (−)‐5′‐DMH‐CBD represents a valuable candidate for further investigation as inhibitor of AEA uptake and a possible new therapeutic agent. Expand
Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors.
- R. Mechoulam, S. Ben-Shabat, +7 authors D. R. Compton
- Biology, Medicine
- Biochemical pharmacology
- 29 June 1995
Upon intravenous administration to mice, 2-Ara-Gl caused the typical tetrad of effects produced by THC: antinociception, immobility, reduction of spontaneous activity, and lowering of the rectal temperature. Expand
Isolation, Structure, and Partial Synthesis of an Active Constituent of Hashish
strongly solvated than triple ions,lb-5 the difference being greater for cations of smaller radii, leading to a trend to smaller K with decreasing cationic radii. Both effects, in opposite… Expand
An endogenous cannabinoid (2-AG) is neuroprotective after brain injury
It is shown that, after injury to the mouse brain, 2-AG may have a neuroprotective role in which the cannabinoid system is involved and this effect was dose-dependently attenuated by SR-141761A, an antagonist of the CB1 cannabinoid receptor. Expand
Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb.
- A. Izzo, F. Borrelli, R. Capasso, V. Di Marzo, R. Mechoulam
- Trends in pharmacological sciences
- 1 October 2009
Cannabidiol and Delta(9)-tetrahydrocannabivarin, a novel CB(1) antagonist which exerts potentially useful actions in the treatment of epilepsy and obesity are given special emphasis. Expand
Peripheral cannabinoid receptor, CB2, regulates bone mass.
- O. Ofek, M. Karsak, +10 authors I. Bab
- Proceedings of the National Academy of Sciences…
- 17 January 2006
It is shown that CB2-deficient mice have a markedly accelerated age-related trabecular bone loss and cortical expansion, although cortical thickness remains unaltered, demonstrating that the endocannabinoid system is essential for the maintenance of normal bone mass by osteoblastic and osteoclastic CB2 signaling. Expand
The endocannabinoid system and the brain.
Research on the actions of the endocannabinoid system on anxiety, depression, neurogenesis, reward, cognition, learning, and memory, and the effects are at times biphasic--lower doses causing effects opposite to those seen at high doses. Expand