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Highly efficient circulating tumor cell isolation from whole blood and label-free enumeration using polymer-based microfluidics with an integrated conductivity sensor.
A novel microfluidic device that can selectively and specifically isolate exceedingly small numbers of circulating tumor cells (CTCs) through a monoclonal antibody (mAB) mediated process by samplingExpand
Surface modification of poly(methyl methacrylate) used in the fabrication of microanalytical devices.
We report here the chemical modification of poly(methyl methacrylate) (PMMA) surfaces by their reaction with the monoanion of alpha,omega-diaminoalkanes (aminolysis reaction) to yieldExpand
Controlled nanofabrication of highly oriented pyrolytic graphite with the scanning tunneling microscope
The formation and selective etching of recessed features of various shapes in highly oriented pyrolytic graphite (HOPG) in air were accomplished by use of the scanning tunneling microscope withExpand
Designing highly specific biosensing surfaces using aptamer monolayers on gold.
To build highly specific surfaces using aptamer affinity reagents, the effects of linker and coadsorbents were investigated for maximizing target binding and specificity for aptamer-basedExpand
Fabrication of DNA microarrays onto poly(methyl methacrylate) with ultraviolet patterning and microfluidics for the detection of low-abundant point mutations.
We have developed a simple ultraviolet (UV)-photomodification protocol using poly(methyl methacrylate) and polycarbonate to produce functional scaffolds consisting of carboxylic groups that allowExpand
Redox-responsive delivery systems.
  • R. McCarley
  • Chemistry, Medicine
  • Annual review of analytical chemistry
  • 18 June 2012
Stimuli-responsive systems for the transport and delivery of materials to a given location at a specific time are highly valuable in numerous applications. The characteristics of the delivery systemExpand
Effect of linker structure on surface density of aptamer monolayers and their corresponding protein binding efficiency.
A systematic study is reported on the effect of linker size and its chemical composition toward ligand binding to a surface-immobilized aptamer, measured using surface plasmon resonance. The results,Expand
Microarrays assembled in microfluidic chips fabricated from poly(methyl methacrylate) for the detection of low-abundant DNA mutations.
Low-density arrays were assembled into microfluidic channels hot-embossed in poly(methyl methacrylate) (PMMA) to allow the detection of low-abundant mutations in gene fragments (K-ras) that carryExpand
Redox-triggered contents release from liposomes.
An exciting new direction in responsive liposome research is endogenous triggering of liposomal payload release by overexpressed enzyme activity in affected tissues and offers the unique possibilityExpand
Surface modification of polymer-based microfluidic devices
Abstract We report the chemical modification of poly(methyl methacrylate) (PMMA), and poly(carbonate) (PC) surfaces for applications in microfluidic systems. For PMMA, a reaction of the surfaceExpand