• Publications
  • Influence
Biological Insights From 108 Schizophrenia-Associated Genetic Loci
TLDR
Associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses.
A review of MRI findings in schizophrenia
Hyperactivity and hyperconnectivity of the default network in schizophrenia and in first-degree relatives of persons with schizophrenia
TLDR
Among patients, the magnitude of MPFC task suppression negatively correlated with default connectivity, suggesting an association between the hyperactivation and hyperconnectivity in schizophrenia.
Control of sleep and wakefulness.
TLDR
Genetic studies suggest that brain mechanisms controlling waking and NREM sleep are strongly conserved throughout evolution, underscoring their enormous importance for brain function.
Activation of Ventrolateral Preoptic Neurons During Sleep
TLDR
The retrograde tracer cholera toxin B, in combination with FOS immunocytochemistry, was used to show that sleep-activated ventrolateral preoptic neurons innervate the tuberomammillary nucleus, a posterior hypothalamic cell group thought to participate in the modulation of arousal.
Adenosine: a mediator of the sleep-inducing effects of prolonged wakefulness.
TLDR
The data reported here suggest that the major criteria for a neural sleep factor mediating the somnogenic effects of prolonged wakefulness are satisfied by adenosine, a neuromodulator whose extracellular concentration increases with brain metabolism and which, in vitro, inhibits basal forebrain cholinergic neurons.
A review of diffusion tensor imaging studies in schizophrenia.
Sleep cycle oscillation: reciprocal discharge by two brainstem neuronal groups.
During the sleep cycle in cats, neurons localized to the posterolateral pole of the nucleus locus coeruleus and the nucleus subcoeruleus undergo discharge rate changes that are the opposite of those
Gamma frequency-range abnormalities to auditory stimulation in schizophrenia.
TLDR
These data provide new information on selective deficits in early-stage sensory processing in schizophrenia, a failure to support the entrainment of intrinsic gamma-frequency oscillators.
...
...