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Mdm2 promotes the rapid degradation of p53
The p53 tumour-suppressor protein exerts antiproliferative effects, including growth arrest and apoptosis, in response to various types of stress1. The activity of p53 is abrogated by mutations thatExpand
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Generation of oscillations by the p53-Mdm2 feedback loop: a theoretical and experimental study.
The intracellular activity of the p53 tumor suppressor protein is regulated through a feedback loop involving its transcriptional target, mdm2. We present a simple mathematical model suggesting that,Expand
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ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage.
The p53 tumor suppressor protein, a key regulator of cellular responses to genotoxic stress, is stabilized and activated after DNA damage. The rapid activation of p53 by ionizing radiation andExpand
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Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage.
The p53 tumor-suppressor protein, a key regulator of cellular responses to genotoxic stress, is stabilized and activated after DNA damage. This process is associated with posttranslationalExpand
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MDM2 Suppresses p73 Function without Promoting p73 Degradation
ABSTRACT The newly identified p53 homolog p73 can mimic the transcriptional activation function of p53. We investigated whether p73, like p53, participates in an autoregulatory feedback loop withExpand
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Regulation of p53: intricate loops and delicate balances.
The p53 tumor suppressor protein provides a major anti-cancer defense mechanism, as underscored by the fact that the p53 gene is the most frequent target for genetic alterations in human cancer.Expand
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Regulation of p53
Abstract: The p53 tumor suppressor protein provides a major anti‐cancer defense mechanism, as underscored by the fact that the p53 gene is the most frequent target for genetic alterations in humanExpand
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The loss of mdm2 induces p53 mediated apoptosis
The p53 tumor suppressor gene product is negatively regulated by the product of its downstream target, mdm2. The deletion of mdm2 in the mouse results in embryonic lethality at 5.5 days post coitumExpand
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The role of DNA repair genes in recombination between repeated sequences in yeast.
The presence of repeated sequences in the genome represents a potential source of karyotypic instability. Genetic control of recombination is thus important to preserve the integrity of the genome.Expand
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Requirement for Mdm2 in the survival effects of Bcr-Abl and interleukin 3 in hematopoietic cells.
The p53/Mdm2 pathway plays an important role in the induction of cell cycle arrest or apoptosis in response to genotoxic stress. Both the oncogene Bcr-Abl and physiological growth factors such asExpand
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