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Coagulanolide, a withanolide from Withania coagulans fruits and antihyperglycemic activity.
The results provide further support to explain the traditional use of W. coagulans as antihyperglycemic cum antidyslipidemic agent by the traditional medical practitioners. Expand
Anti-osteoporotic constituents from Indian medicinal plants.
Findings lend support to the use of Allophylus serratus, Cissus quadrangularis and Vitex negundo in traditional medicine. Expand
Proteasome inhibition mediates p53 reactivation and anti-cancer activity of 6-Gingerol in cervical cancer cells
6G treatment induced significant reduction of tumor volume, tumor weight, proteasome inhibition and p53 accumulation in HeLa xenograft tumor cells in vivo and the 6G treatment was devoid of toxic effects as it did not affect body weights, hematological and osteogenic parameters. Expand
Antilymphoproliferative activity of ethanolic extract of Boerhaavia diffusa roots.
B. diffusa extract inhibited the growth of several cell lines of mouse and human origin, such as mouse macrophage cells, human monocytic cells, mouse fibroblast cells, and human T cells. Expand
Immunosuppressive properties of flavonoids isolated from Boerhaavia diffusa Linn.
Plant extracts have been widely evaluated for possible immunomodulatory properties. We have earlier reported that ethanolic extract of Boerhaavia diffusa root, a plant used in Indian traditionalExpand
Anti-hyperglycaemic, lipid lowering and anti-oxidant properties of (6)-gingerol in db/db mice
) lowered fasting blood glucose and improved the glucose tolerance in db/db mice. Oral administration of [6]-gingerol also significantly (p < 0.05) decreased plasma triglycerides (TG), totalExpand
Protective effect of Acorus calamus against acrylamide induced neurotoxicity
The results suggest that the neurobehavioural changes produced by ACR may be prevented following treatment with Acorus calamus rhizomes, while the dopamine receptors decreased compared with the ACR treated rats. Expand
Methoxylated isoflavones, cajanin and isoformononetin, have non‐estrogenic bone forming effect via differential mitogen activated protein kinase (MAPK) signaling
It is suggested that cajanin is more potent than isoformononetin in accelerating peak bone mass achievement and this work represents the first attempt to elucidate structure‐activity relationship between the two methoxylated isoflavones regarding their effects in osteoblasts and bone formation. Expand
Immunomodulation by ethanolic extract of Boerhaavia diffusa roots.
This study demonstrates immunosuppressive potential of ethanolic extract of B. diffusa extract on various in vitro tests such as human natural killer cell cytotoxicity, production of nitric oxide in mouse macrophage cells, IL-2 and TNF-alpha in human PBMCs. Expand
Withania somnifera inhibits NF‐κB and AP‐1 transcription factors in human peripheral blood and synovial fluid mononuclear cells
The WS extract significantly suppressed lipopolysaccharide (LPS) induced production of proinflammatory cytokines TNF‐α, IL‐1β and IL‐12p40 in normal individuals and RA patients, but had no effect on IL‐6 production at the protein and transcript level. Expand