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Pharmacodynamics of Vecuronium and Atracurium in the Obese Surgical Patient
The effect of obesity on the duration of action of the nondepolarizing muscle relaxants atracurium and vecuronium was studied in 28 neurosurgical patients. In obese patients given vecuronium (0.1Expand
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Dose-Ranging Study in Younger Adult and Elderly Patients of ORG 9487, a New, Rapid-Onset, Short-Duration Muscle Relaxant
The purpose of this multicenter, randomized, assessor-blind placebo-controlled study was to determine which of five doses of the new, rapid-onset neuromuscular relaxant, ORG 9487, provided both goodExpand
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Pharmacokinetics and Pharmacodynamics of Vecuronium in the Obese Surgical Patient
The effect of obesity on the disposition and action of vecuronium was studied in 14 surgical patients. After induction of anesthesia with thiopental and maintenance of anesthesia by inhalation ofExpand
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Cerebral Blood Flow Reactivity to Changes in Carbon Dioxide Calculated Using End-Tidal versus Arterial Tensions
We retrospectively examined arterial and endtidal estimations of CO2 tension used to calculate cerebrovascular reactivity in 68 anesthetized patients. CBF was measured using the intravenous 133XeExpand
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Pharmacokinetics and Pharmacodynamics of Rocuronium (Org 9426) in Elderly Surgical Patients
The effects of age on the pharmacokinetic and pharmacodynamic responses to rocuronium (Org 9426) were studied in 20 elderly (>70 yr) and 20 younger control patients (<60 yr) during N2O/O2, fentanylExpand
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Cerebrospinal Fluid Levels of d‐Tubocurarine in Man
Using radioimmunoassay, d-tubocurarine (dTc) was found in the cerebrospinal fluid (CSF) of man after intravenous injection. When dTc was administered in a single dose (0.3 mg/kg) to nine patients,Expand
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Aging Alters the Pharmacokinetics of Pyridostigmine
The duration of the antagonism to neuromuscular blockade produced by pyridostigmine is prolonged in elderly patients, and a pharmacokinetic explanation was sought.Ten elderly (71-85 yr) and 10Expand
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