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Grafts of Schwann cells engineered to express PSA-NCAM promote functional recovery after spinal cord injury.
Schwann cells (SCs) are among the most attractive cellular candidates for the development of remyelination therapies for CNS lesions. Yet, their integration in the CNS is inhibited by astrocytes andExpand
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The neuron–glia signal β‐neuregulin promotes Schwann cell motility via the MAPK pathway
Neuregulins constitute a family of related growth factors that play important roles in Schwann cell development and maturation. We investigated the involvement of β‐neuregulin in Schwann cellExpand
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The metabolism of neuropeptides. The hydrolysis of peptides, including enkephalins, tachykinins and their analogues, by endopeptidase-24.11.
Endopeptidase-24.11 (EC, purified to homogeneity from pig kidney, was shown to hydrolyse a wide range of neuropeptides, including enkephalins, tachykinins, bradykinin, neurotensin,Expand
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A Critical Role for HSP90 in Cancer Cell Invasion Involves Interaction with the Extracellular Domain of HER-2*
HSP90 is a ubiquitously expressed molecular chaperone that controls the folding, assembly, intracellular disposition, and proteolytic turnover of many proteins, most of which are involved in signalExpand
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Functional cross-talk between the cellular prion protein and the neural cell adhesion molecule is critical for neuronal differentiation of neural stem/precursor cells.
Cellular prion protein (PrP) is prominently expressed in brain, in differentiated neurons but also in neural stem/precursor cells (NPCs). The misfolding of PrP is a central event in prion diseases,Expand
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Management of infants with Pierre Robin sequence.
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Schwann cells genetically engineered to express PSA show enhanced migratory potential without impairment of their myelinating ability in vitro
Schwann cells, the myelin‐forming cells of the PNS, are attractive candidates for remyelination therapy as they can remyelinate CNS axons. Yet their integration in CNS tissue appears hampered, atExpand
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Aberrant localization of the neuronal class III beta-tubulin in astrocytomas.
BACKGROUND The class III beta-tubulin isotype (betaIII) is widely regarded as a neuronal marker in development and neoplasia. In previous work, we have shown that the expression of betaIII inExpand
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Substance P and [Leu]enkephalin are hydrolyzed by an enzyme in pig caudate synaptic membranes that is identical with the endopeptidase of kidney microvilli.
The hydrolysis of [Leu]enkephalin and substance P by purified pig kidney endopeptidase (EC and synaptic membranes prepared from pig caudate nuclei has been compared. The hydrolysis of anExpand
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Schwann cell transplantation for CNS repair.
Demyelination occurs in several central nervous system (CNS) disorders, including multiple sclerosis, viral infection and spinal cord injury and can result in severe functional impairment. ThereforeExpand
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