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NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease.
TLDR
The hypothesis that free radicals from NADPH oxidase in hepatic Kupffer cells play a predominant role in the pathogenesis of early alcohol-induced hepatitis by activating NF-kappaB, which activates production of cytotoxic TNF-alpha is strongly supported.
Mitochondrial Dysfunction in SOD1G93A-Bearing Astrocytes Promotes Motor Neuron Degeneration: Prevention by Mitochondrial-Targeted Antioxidants
TLDR
Evidence that mitochondrial dysfunction in astrocytes critically influences motor neuron survival is provided and the potential pharmacological utility of mitochondrial-targeted antioxidants in ALS treatment is supported.
Phenoxyl Free Radical Formation during the Oxidation of the Fluorescent Dye 2′,7′-Dichlorofluorescein by Horseradish Peroxidase
TLDR
It is demonstrated that DCFH cannot be used conclusively to measure superoxide or hydrogen peroxide formation in cells undergoing oxidative stress.
The role of Kupffer cell oxidant production in early ethanol-induced liver disease.
In vivo lipid‐derived free radical formation by NADPH oxidase in acute lung injury induced by lipopolysaccharide: a model for ARDS
TLDR
In vivo lipid‐derived free radical formation by NADPH oxidase in acute lung injury induced by lipopolysaccharide is investigated, using rats treated with intratracheal instillation of LPS as a model for ARDS.
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