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Eosinophil-associated TGF-beta1 mRNA expression and airways fibrosis in bronchial asthma.
TLDR
Evidence is provided that TGF-beta1 may play a role in the fibrotic changes occurring within asthmatic airways and that activated eosinophils are a major source of this cytokine.
A link between chronic asthma and chronic infection.
TLDR
A significant number of patients with chronic stable asthma demonstrate the presence of Mycoplasma species, Chlamydia species, or both in their airways, with the distinguishing feature of increased mast cell number, which may help to understand the pathophysiology of asthma and new treatment options.
The effect of polymorphisms of the beta(2)-adrenergic receptor on the response to regular use of albuterol in asthma.
TLDR
Polymorphisms of the beta(2)-AR may influence airway responses to regular inhaled beta-agonist treatment as well as other differences in asthma outcomes that were investigated.
Bronchoscopic evaluation of severe asthma. Persistent inflammation associated with high dose glucocorticoids.
TLDR
Investigating the presence and type of airway inflammation in patients with severe asthma suggests that inflammation remains in severe symptomatic asthmatics despite treatment with high dose glucocorticoids, which may be due to the severity of disease, glucOCorticoid treatment, or other as yet undefined factors.
Cardiorespiratory events recorded on home monitors: Comparison of healthy infants with those at increased risk for SIDS.
TLDR
Test the hypothesis that preterm infants, siblings of infants who died of SIDS, and infants who have experienced an idiopathic, apparent life-threatening event have a greater risk of cardiorespiratory events than healthy term infants.
Expression of IL-12 and IL-13 mRNA in asthma and their modulation in response to steroid therapy.
TLDR
An in vivo role for IL-12 and IL-13 in modulating allergic responses is suggested and the notion that the clinical effects of glucocorticoids are at least partially mediated through the modulation of cytokine production is supported.
Long-acting beta2-agonist monotherapy vs continued therapy with inhaled corticosteroids in patients with persistent asthma: a randomized controlled trial.
TLDR
Patients with persistent asthma well controlled by low doses of triamcinolone cannot be switched to salmeterol monotherapy without risk of clinically significant loss of asthma control.
Alveolar tissue inflammation in asthma.
TLDR
It is suggested that eosinophils and macrophages accumulate to a greater extent in the alveolar tissue and these changes contribute more to the variation in lung function compared with inflammation in the more proximal tissue.
Genetic polymorphisms of the beta 2-adrenergic receptor in nocturnal and nonnocturnal asthma. Evidence that Gly16 correlates with the nocturnal phenotype.
TLDR
The Gly16 polymorphism of the beta 2AR, which imparts an enhanced downregulation of receptor number, is overrepresented in nocturnal asthma and appears to be an important genetic factor in the expression of this asthmatic phenotype.
Differential expression of lymphocyte homing receptors by human memory/effector T cells in pulmonary versus cutaneous immune effector sites
TLDR
Tissue microenvironments play a major role in determining the character of local T cell infiltrates via their ability to import and retain memory/effector subsets selectively or, more generally, depending on the intensity of local inflammatory stimuli.
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