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The ACVD task force on canine atopic dermatitis: forewords and lexicon.
Validation of CADESI-03, a severity scale for clinical trials enrolling dogs with atopic dermatitis.
A third version of the Canine Atopic Dermatitis Extent and Severity Index was designed and found to exhibit acceptable content, construct, criterion, and inter- and intra-observer reliability and sensitivity to change and is recommended as a validated tool for assessment of disease severity in clinical trials testing the efficacy of interventions in dogs with AD. Expand
Performance characteristics of a monoclonal antibody cocktail-based ELISA for detection of allergen-specific IgE in dogs and comparison with a high affinity IgE receptor-based ELISA.
The results demonstrate that the macELISA is reproducible and the results are comparable to the high affinity IgE receptor based ELISA within and between laboratories. Expand
Effects of age and allergen exposure on transepidermal water loss in a house dust mite-sensitized beagle model of atopic dermatitis.
It is concluded that the house dust mite-sensitized atopic beagle dogs used in this study have altered barrier function in 'atopic' areas and that such differences are more evident in young individuals and are aggravated by allergen exposure. Expand
Unravelling the skin barrier: a new paradigm for atopic dermatitis and house dust mites.
It is proposed that the paradigm of canine AD as primarily due to immunologic aberration ('inside/outside') should be shifted to include a primary defect in barrier function ('outside/inside'). Expand
Investigation on the association between atopic dermatitis and the development of mycosis fungoides in dogs: a retrospective case-control study.
An association between AD and MF in dogs is suggested and future studies are necessary to confirm this finding and to investigate the pathogenic mechanisms involved in this association. Expand
PCR-based detection of Pythium and Lagendium DNA in frozen and ethanol-fixed animal tissues.
Evaluated Pythium insidiosum- and Lagenidium-specific nested PCR assays to the detection of oomycete DNA in animal tissues found them to be effective in detecting pythiosis and lagenidiosis but not for any of the other tissues. Expand
The ACVD task force on canine atopic dermatitis (II): genetic factors.
Canine atopic dermatitis is commonly diagnosed in pruritic animals and the mode of inheritance and genetic mutations underlying this disease currently remain elusive. Expand
Canine models of atopic dermatitis: a useful tool with untapped potential.
Interestingly, decreased epidermal filaggrin expression and disturbed extrusion of lamellar bodies by keratinocytes are present in these dogs, as well as increased transepidermal water loss, particularly in sites characteristically affected by AD. Expand
Pharmacokinetics of pentoxifylline in dogs after oral and intravenous administration.
In dogs, oral administration of 15 mg of PTX/kg results in plasma concentrations similar to those produced by therapeutic doses in humans, and a three-times-a-day dosing regimen is the most appropriate. Expand