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Triclosan: A critical review of the experimental data and development of margins of safety for consumer products
TLDR
Exposure to triclosan in consumer products is not expected to cause adverse health effects in children or adults who use these products as intended and a Benchmark Dose (BMDL10) was developed based on kidney toxicity in the hamster.
Effects of fixation on RNA extraction and amplification from laser capture microdissected tissue
TLDR
Optimal fixation protocols for LCM analysis will facilitate the examination of gene expression in specific cell populations, accelerating investigations of the molecular differences responsible for the phenotypic changes observed during carcinogenesis.
The Orphan Nuclear Receptor Constitutive Active/Androstane Receptor Is Essential for Liver Tumor Promotion by Phenobarbital in Mice
TLDR
The results indicate that CAR is the molecular target of promotion by Phenobarbital and that activation of this receptor is an essential requirement for liver tumor development.
Proliferative and Nonproliferative Lesions of the Rat and Mouse Hepatobiliary System
TLDR
This publication is to provide a standardized nomenclature and differential diagnosis for classifying microscopic lesions observed in the hepatobiliary system of laboratory rats and mice, with color microphotographs illustrating examples of some lesions.
Di-(2-ethylhexyl) phthalate suppresses estradiol and ovulation in cycling rats.
TLDR
Exposure to DEHP resulted in hypoestrogenic anovulatory cycles and polycystic ovaries in adult female rats, although DEHP-treated rats ovulated after treatment with human chorionic hormone.
Classification of Proliferative Pulmonary Lesions of the Mouse
TLDR
A series of discussions was initiated by a panel of human, veterinary, and experimental pathologists during the Mouse Models of Human Cancers Consortium (NIH/National Cancer Institute) workshop on mouse models of lung cancer, and a new practical classification scheme was recommended that would allow easier comparison between human and mouse lung neoplasms.
New Insights into Functional Aspects of Liver Morphology
TLDR
Findings regarding the functional heterogeneity of the various liver cell types, including hepatocytes, hepatic stellate cells, sinusoidal endothelia, and Kupffer cells, are providing new insights into the understanding of the development, prevention and treatment of liver disease.
Dose-response relationship between O6-methylguanine formation in Clara cells and induction of pulmonary neoplasia in the rat by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
TLDR
The data suggest that the majority of neoplasms in the lung begin as type II cell proliferations with progression to adenomas and carcinomas within the areas of hyperplasia and the lack of agreement between biochemical and morphological findings makes it difficult to hypothesize a cell of origin for the pulmonary neoplasm.
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