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Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1
Glucagon-like peptide-1 (GLP-1), released from gut endocrine L cells in response to glucose, regulates appetite, insulin secretion, and gut motility. How glucose given orally, but not systemically,Expand
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T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1
Dietary sugars are transported from the intestinal lumen into absorptive enterocytes by the sodium-dependent glucose transporter isoform 1 (SGLT1). Regulation of this protein is important for theExpand
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Detection of Sweet and Umami Taste in the Absence of Taste Receptor T1r3
The tastes of sugars (sweet) and glutamate (umami) are thought to be detected by T1r receptors expressed in taste cells. Molecular genetics and heterologous expression implicate T1r2 plus T1r3 as aExpand
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Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac
The ability to taste the sweetness of carbohydrate-rich foodstuffs has a critical role in the nutritional status of humans. Although several components of bitter transduction pathways have beenExpand
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A transient receptor potential channel expressed in taste receptor cells
We used differential screening of cDNAs from individual taste receptor cells to identify candidate taste transduction elements in mice. Among the differentially expressed clones, one encoded Trpm5, aExpand
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Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut
Tuft cells help contain parasites Trillions of microbes inhabit our guts, including worms and other parasites. Epithelial cells that line the gut orchestrate parasite-targeted immune responses.Expand
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Afferent neurotransmission mediated by hemichannels in mammalian taste cells
In mammalian taste buds, ionotropic P2X receptors operate in gustatory nerve endings to mediate afferent inputs. Thus, ATP secretion represents a key aspect of taste transduction. Here, weExpand
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The Cysteine-rich Region of T1R3 Determines Responses to Intensely Sweet Proteins*
  • P. Jiang, Q. Ji, +4 authors M. Max
  • Medicine, Chemistry
  • Journal of Biological Chemistry
  • 22 October 2004
A wide variety of chemically diverse compounds taste sweet, including natural sugars such as glucose, fructose, sucrose, and sugar alcohols, small molecule artificial sweeteners such as saccharin andExpand
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Trpm5 null mice respond to bitter, sweet, and umami compounds.
Trpm5 is a calcium-activated cation channel expressed selectively in taste receptor cells. A previous study reported that mice with an internal deletion of Trpm5, lacking exons 15-19 encodingExpand
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Immunocytochemical evidence for co-expression of Type III IP3 receptor with signaling components of bitter taste transduction
BackgroundTaste receptor cells are responsible for transducing chemical stimuli into electrical signals that lead to the sense of taste. An important second messenger in taste transduction is IP3,Expand
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