R. Marfella

Publications261
h-index58
Citations16,438
Highly Influential Citations544
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Effect of a mediterranean-style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome: a randomized trial.
CONTEXT The metabolic syndrome has been identified as a target for dietary therapies to reduce risk of cardiovascular disease; however, the role of diet in the etiology of the metabolic syndrome is… Expand
  • 1,155
  • 67
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Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women: a randomized trial.
CONTEXT Obesity is an independent risk factor for cardiovascular disease, which may be mediated by increased secretion of proinflammatory cytokines by adipose tissue. OBJECTIVE To determine the… Expand
  • 1,453
  • 54
  • PDF
Inflammatory Cytokine Concentrations Are Acutely Increased by Hyperglycemia in Humans: Role of Oxidative Stress
Background—Circulating levels of interleukin-6 (IL-6) and tumor necrosis factor-&agr; (TNF-&agr;) are elevated in diabetic patients. We assessed the role of glucose in the regulation of circulating… Expand
  • 1,562
  • 49
Postprandial endothelial activation in healthy subjects and in type 2 diabetic patients: role of fat and carbohydrate meals.
OBJECTIVES To compare the effect of a high-fat meal and a high-carbohydrate meal (pizza), with and without antioxidant vitamins, on endothelial activation in healthy subjects and in patients with… Expand
  • 537
  • 34
Reduction of Inflammatory Cytokine Concentrations and Improvement of Endothelial Functions in Obese Women After Weight Loss Over One Year
Background—Visceral fat is a key regulator site for the process of inflammation, and atherosclerotic lesions are essentially an inflammatory response. Methods and Results—Fifty-six healthy… Expand
  • 997
  • 31
Effect of lifestyle changes on erectile dysfunction in obese men: a randomized controlled trial.
CONTEXT Healthy lifestyle factors are associated with maintenance of erectile function in men. OBJECTIVE To determine the effect of weight loss and increased physical activity on erectile and… Expand
  • 597
  • 16
  • PDF
Effect of Weight Loss and Lifestyle Changes on Vascular Inflammatory Markers in Obese Women
THE RATE OF OBESITY AND THE numbers of dieters are increasing in parallel. More than 54 million Americans are currently dieting, yet the epidemic of obesity continues virtually unabated with no sign… Expand
  • 253
  • 14
High proportions of erectile dysfunction in men with the metabolic syndrome.
Erectile dysfunction is an important cause of decreased quality of life in men (1,2). Strong epidemiological evidence links the subsequent risk of erectile dysfunction to the presence of… Expand
  • 233
  • 13
  • PDF
Reduction of Oxidative Stress and Inflammation by Blunting Daily Acute Glucose Fluctuations in Patients With Type 2 Diabetes
OBJECTIVE Evaluate the effects of two dipeptidyl peptidase-IV (DPP-4) inhibitors, sitagliptin and vildagliptin, known to have different efficacy on mean amplitude of glycemic excursions (MAGE), on… Expand
  • 180
  • 10
Effect of moderate red wine intake on cardiac prognosis after recent acute myocardial infarction of subjects with Type 2 diabetes mellitus
Background  Oxidative stress and increased inflammation have been reported to be increased in subjects with diabetes and to be involved in the pathogenesis of cardiovascular complications after… Expand
  • 87
  • 8