• Publications
  • Influence
Biowaiver monographs for immediate release solid oral dosage forms: ciprofloxacin hydrochloride.
TLDR
A biowaiver based approval of ciprofloxacin hydrochloride containing IR solid oral dosage forms cannot be recommended for either new multisource drug products or for major scale-up and postapproval changes (variations) to existing drug products. Expand
Modeling drug release from a layered double hydroxide-ibuprofen complex
Abstract Drug delivery by layered double hydroxides (LDHs) is extensively studied due to the capacity of these solids to preserve the active agent and to modify its release rate and bioavailability.Expand
Engineering the Specificity of Antibacterial Fluoroquinolones: Benzenesulfonamide Modifications at C-7 of Ciprofloxacin Change Its Primary Target in Streptococcus pneumoniae from Topoisomerase IV to
TLDR
Data show unequivocally that the C-7 substituent determines not only the potency but also the target preference of fluoroquinolones, which supports one key postulate of the Shen model of quinolone action. Expand
Solubility behavior and biopharmaceutical classification of novel high-solubility ciprofloxacin and norfloxacin pharmaceutical derivatives.
TLDR
The solubility improvement turns the complexes as potential biowaiver candidates from the scientific point of view and may be a good way for developing more dose-efficient formulations. Expand
Release kinetics and up-take studies of model fluoroquinolones from carbomer hydrogels.
TLDR
Hydrogels C-AMFQ behave as a reservoir of AMFQ able to deliver it at a constant rate and would be useful to design topical and or systemic dosage forms. Expand
Enhanced intestinal permeability and oral bioavailability of enalapril maleate upon complexation with the cationic polymethacrylate Eudragit E100.
TLDR
The developed polyelectrolyte-drug complex between enalapril maleate and the cationic polymethacrylate Eudragit E100 are new chemical entities that improve unfavorable properties of a useful drug. Expand
Colloidal properties of amiodarone in water at low concentration.
TLDR
Micellization is an entropy-driven process which is probably caused by a strong dehydration of the amiodarone backbone on micellization and the nature of aggregates below T(K) at different concentrations was determined. Expand
Self-organized nanoparticles based on drug-interpolyelectrolyte complexes as drug carriers
Potential applications in drug delivery from nanostructures composed of two oppositely charged polymethacrylates, eudragit® L100 (EL) and eudragit® EPO (EE), loaded with three model basic drugs (D),Expand
Studies of pilocarpine:carbomer intermolecular interactions.
TLDR
The experiments showed that the pilocarpine complex, prepared by freeze-drying, is a solid amorphous form different from its precursors, thereby offering an interesting alternative for the preparation of extended release matrices. Expand
Self-organized drug-interpolyelectrolyte nanocomplexes loaded with anionic drugs. Characterization and in vitro release evaluation
Fil: Palena, Maria Celeste. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Cordoba. Unidad de Investigacion y Desarrollo en TecnologiaExpand
...
1
2
3
4
5
...