• Publications
  • Influence
Synthesis and biological activity of novel pyrimidinone containing thiazolidinedione derivatives.
A series of pyrimidinone derivatives of thiazolidinediones were synthesized. Their biological activity were evaluated in insulin resistant, hyperglycemic and obese db/db mice. In vitro PPARgammaExpand
  • 44
  • 3
LC-ESI-MS/MS quantification of 4β-hydroxycholesterol and cholesterol in plasma samples of limited volume.
A liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) assay was developed and qualified for analyzing 4β-hydroxycholesterol and cholesterol in 5 μl of human andExpand
  • 20
  • 2
Simple method for the determination of rosiglitazone in human plasma using a commercially available internal standard.
To the best of our knowledge, bioanalytical methods to determine rosiglitazone in human plasma reported in literature use internal standards that are not commercially available. Our purpose was toExpand
  • 33
  • 1
Novel euglycemic and hypolipidemic agents. 1.
A series of [[(heterocyclyl)ethoxy]benzyl]-2,4-thiazolidinediones have been synthesized by the condensation of corresponding aldehyde 1 and 2,4-thiazolidinedione followed by hydrogenation. BothExpand
  • 60
  • 1
HPLC method for the determination of rosiglitazone in human plasma and its application in a clinical pharmacokinetic study.
Rosiglitazone (CAS 155141-29-0, Avandia) is a novel insulin sensitizer used in the treatment of type 2 diabetes. A sensitive high performance liquid chromatography (HPLC) method for its determinationExpand
  • 19
  • 1
Determination of lipoic acid in rat plasma by LC-MS/MS with electrospray ionization: assay development, validation and application to a pharamcokinetic study.
A simple, sensitive and specific LC-MS/MS method for the determination of lipoic acid was developed and validated over the linearity range 5-1000 ng/mL (r2 > 0.99) with 200 microL rat plasma usingExpand
  • 27
  • 1
Polymorphism of dextromethorphan oxidation in South Indian subjects
One hundred fifty‐six unrelated healthy South Indian subjects were phenotyped according to their ability to metabolize dextromethorphan to its O‐demethylated metabolite dextrorphan. Each volunteerExpand
  • 13
  • 1
Synthesis of conformationally constrained analogues of linezolid: structure-activity relationship (SAR) studies on selected novel tricyclic oxazolidinones.
In an effort to discover potent antibacterials based on the entropically favored "bioactive conformation" approach, we have designed and synthesized a series of novel tricyclic molecules mimickingExpand
  • 57
Novel phthalazinone and benzoxazinone containing thiazolidinediones as antidiabetic and hypolipidemic agents.
We report here the synthesis of a series of 5-[4-[2-[substituted phthalazinones-2(or 4)yl]ethoxy]phenylmethyl]thiazolidine-2,4-diones andExpand
  • 66
Bioanalytical considerations for compounds containing free sulfhydryl groups.
Thiol-containing compounds pose bioanalytical challenge in several dimensions due to extreme reactivity of the sulfhydryl group. The development of robust bioanalytical methodology for thiol groupsExpand
  • 27