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Pyruvate-enhanced phosphorylation potential and inotropism in normoxic and postischemic isolated working heart. Near-complete prevention of reperfusion contractile failure.
Bioenergetic and hemodynamic consequences of cellular redox manipulations by 0.2-20 mM pyruvate were compared with those due to adrenergic stress (0.7-1.1 microM norepinephrine) using isolatedExpand
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Mitochondrial metabolism of pyruvate is required for its enhancement of cardiac function and energetics.
UNLABELLED Pyruvate augmentation of contractile function and cytosolic free energy of ATP hydrolysis in myocardium could result from pyruvate catabolism in the mitochondria or from increased ratio ofExpand
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Metabolic Cardioprotection by Pyruvate: Recent Progress
Pyruvate, a natural metabolic fuel and antioxidant in myocardium and other tissues, exerts a variety of cardioprotective actions when provided at supraphysiological concentrations. Pyruvate increasesExpand
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Normobaric hypoxia conditioning reduces blood pressure and normalizes nitric oxide synthesis in patients with arterial hypertension
Objectives Insufficient production and/or increased decomposition of the potent endogenous vasodilator nitric oxide plays an important role in development and progression of arterial hypertension andExpand
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Intermittent Hypoxia: Cause of or Therapy for Systemic Hypertension?
During acute episodes of hypoxia, chemoreceptor-mediated sympathetic activity increases heart rate, cardiac output, peripheral resistance and systemic arterial pressure. However, differentExpand
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Role of Nitric Oxide in Cardiovascular Adaptation to Intermittent Hypoxia
Hypoxia is one of the most frequently encountered stresses in health and disease. The duration, frequency, and severity of hypoxic episodes are critical factors determining whether hypoxia isExpand
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Antioxidant properties of pyruvate mediate its potentiation of beta-adrenergic inotropism in stunned myocardium.
UNLABELLED This study tested the hypothesis that pyruvate's antioxidant actions, particularly its enhancement of the endogenous glutathione system, mediate its potentiation of beta-adrenergicExpand
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Strategic leukocyte depletion reduces pulmonary microvascular pressure and improves pulmonary status post-cardiopulmonary bypass
Cardiopulmonary bypass (CPB) precipitates inflammation that causes marked pulmonary dysfunction. Leukocyte filtration has been proposed to reduce these deleterious effects. Other studies show anExpand
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Acetoacetate augments beta-adrenergic inotropism of stunned myocardium by an antioxidant mechanism.
Blunted beta-adrenergic inotropism in stunned myocardium is restored by pharmacological (N-acetylcysteine) and metabolic (pyruvate) antioxidants. The ketone body acetoacetate is a natural myocardialExpand
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Hypoxic preconditioning of ischaemic canine myocardium.
OBJECTIVE The aim was to test whether a brief period of non-ischaemic hypoxia can precondition myocardium. METHODS 60 anaesthetised adult mongrel dogs of either sex underwent 60 min occlusion ofExpand
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