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AMPA receptor trafficking and synaptic plasticity.
Activity-dependent changes in synaptic function are believed to underlie the formation of memories. Two prominent examples are long-term potentiation (LTP) and long-term depression (LTD), whose… Expand
Driving AMPA receptors into synapses by LTP and CaMKII: requirement for GluR1 and PDZ domain interaction.
- Y. Hayashi, S. Shi, J. A. Esteban, A. Piccini, J. C. Poncer, R. Malinow
- Biology, Medicine
- 24 March 2000
To elucidate mechanisms that control and execute activity-dependent synaptic plasticity, alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptors (AMPA-Rs) with an electrophysiological tag… Expand
Subunit-Specific Rules Governing AMPA Receptor Trafficking to Synapses in Hippocampal Pyramidal Neurons
AMPA-type glutamate receptors (AMPA-Rs) mediate a majority of excitatory synaptic transmission in the brain. In hippocampus, most AMPA-Rs are hetero-oligomers composed of GluR1/GluR2 or GluR2/GluR3… Expand
Activation of postsynaptically silent synapses during pairing-induced LTP in CA1 region of hippocampal slice
LONG-TERM potentiation (LTP) is an enhancement of synaptic strength that can be produced by pairing of presynaptic activity with postsynaptic depolarization1. LTP in the hippocampus has been… Expand
PKA phosphorylation of AMPA receptor subunits controls synaptic trafficking underlying plasticity
- J. Esteban, S. Shi, C. Wilson, M. Nuriya, R. Huganir, R. Malinow
- Biology, Medicine
- Nature Neuroscience
- 1 February 2003
The regulated incorporation of AMPA receptors into synapses is important for synaptic plasticity. Here we examine the role of protein kinase A (PKA) in this process. We found that PKA phosphorylation… Expand
NMDA Receptor Subunit Composition Controls Synaptic Plasticity by Regulating Binding to CaMKII
Calcium entry through postsynaptic NMDA-Rs and subsequent activation of CaMKII trigger synaptic plasticity in many brain regions. Active CaMKII can bind to NMDA-Rs, but the physiological role of this… Expand
Ras and Rap Control AMPA Receptor Trafficking during Synaptic Plasticity
Recent studies show that AMPA receptor (-R) trafficking is important in synaptic plasticity. However, the signaling controlling this trafficking is poorly understood. Small GTPases have diverse… Expand
APP Processing and Synaptic Function
A large body of evidence has implicated Abeta peptides and other derivatives of the amyloid precursor protein (APP) as central to the pathogenesis of Alzheimer's disease (AD). However, the functional… Expand
Rapid spine delivery and redistribution of AMPA receptors after synaptic NMDA receptor activation.
To monitor changes in alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor distribution in living neurons, the AMPA receptor subunit GluR1 was tagged with green fluorescent protein… Expand
AMPAR Removal Underlies Aβ-Induced Synaptic Depression and Dendritic Spine Loss
Beta amyloid (Abeta), a peptide generated from the amyloid precursor protein (APP) by neurons, is widely believed to underlie the pathophysiology of Alzheimer's disease. Recent studies indicate that… Expand