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A genomic storm in critically injured humans
Critical injury in humans induces a genomic storm with simultaneous changes in expression of innate and adaptive immunity genes.
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Genomic responses in mouse models poorly mimic human inflammatory diseases
A cornerstone of modern biomedical research is the use of mouse models to explore basic pathophysiological mechanisms, evaluate new therapeutic approaches, and make go or no-go decisions to carry newExpand
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Fat embolism syndrome. A 10-year review.
BACKGROUND The effect of recent advances in critical care and the emphasis on early fracture fixation in patients with fat embolism syndrome (FES) are unknown. OBJECTIVE To better define FES inExpand
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Trauma mortality patterns in three nations at different economic levels: implications for global trauma system development.
BACKGROUND Whereas organized trauma care systems have decreased trauma mortality in the United States, trauma system design has not been well addressed in developing nations. We sought to determineExpand
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Patterns of Errors Contributing to Trauma Mortality: Lessons Learned From 2594 Deaths
Objective:To identify patterns of errors contributing to inpatient trauma deaths. Methods:All inpatient trauma deaths at a high-volume level I trauma center from 1996 to 2004 inclusive were audited.Expand
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Outcome after hemorrhagic shock in trauma patients.
BACKGROUND It is essential to identify patients at high risk of death and complications for future studies of interventions to decrease reperfusion injury. METHODS We conducted an inception cohortExpand
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Haemorrhage control in severely injured patients
Most surgeons have adopted damage control surgery for severely injured patients, in which the initial operation is abbreviated after control of bleeding and contamination to allow ongoingExpand
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Fresh frozen plasma is independently associated with a higher risk of multiple organ failure and acute respiratory distress syndrome.
BACKGROUND Blood transfusion is known to be an independent risk factor for mortality, multiple organ failure (MOF), acute respiratory distress syndrome (ARDS), and nosocomial infection after injury.Expand
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Effect of chlorhexidine whole-body bathing on hospital-acquired infections among trauma patients.
OBJECTIVE To demonstrate whether daily bathing with cloths impregnated with 2% chlorhexidine gluconate will decrease colonization of resistant bacteria and reduce the rates of health care-associatedExpand
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Randomized, Prospective Trial of Antioxidant Supplementation in Critically Ill Surgical Patients
ObjectiveTo determine the effectiveness of early, routine antioxidant supplementation using &agr;-tocopherol and ascorbic acid in reducing the rate of pulmonary morbidity and organ dysfunction inExpand
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