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Localization of D1 and D2 dopamine receptors in brain with subtype-specific antibodies.
Five or more dopamine receptor genes are expressed in brain. However, the pharmacological similarities of the encoded D1-D5 receptors have hindered studies of the localization and functions of theExpand
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Genetic Deletion of Trace Amine 1 Receptors Reveals Their Role in Auto-Inhibiting the Actions of Ecstasy (MDMA)
“Ecstasy” [3,4-methylenedioxymetamphetamine (MDMA)] is of considerable interest in light of its prosocial properties and risks associated with widespread recreational use. Recently, it was found toExpand
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The Tetrahydroisoquinoline Derivative SB269,652 Is an Allosteric Antagonist at Dopamine D3 and D2 Receptors
In view of the therapeutic importance of dopamine D3 and D2 receptors, there remains considerable interest in novel ligands. Herein, we show that the tetrahydroisoquinoline 1H-indole-2-carboxylicExpand
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Inhibition of nitric oxide synthase dramatically potentiates seizures induced by kainic acid and pilocarpine in rats
We investigated whether the severity of convulsions evoked by kainic acid and pilocarpine is modified in nitric oxide synthase inhibitor-treated rats. We found that chronic treatment (4 days) withExpand
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Role of Brainstem Structures in Seizures Initiated from the Deep Prepiriform Cortex of Rats
Summary: Previous studies showed that brainstem sei zures can still be evoked after transections that separate forebrain from brainstem. We sought to determine wheth er forebrain‐evokedExpand
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(+)MK-801 prevents the DDC-induced enhancement of MPTP toxicity in mice
In order to reach deeper insight into the mechanism of diethyldithiocarbamate (DDC)-induced enhancement of MPTP toxicity in mice, MK-801, a non-competitive antagonist of NMDA receptors, has been usedExpand
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Striatal increase of neurotrophic factors as a mechanism of nicotine protection in experimental parkinsonism
SummaryThe repeated finding of an apparent protective effect of cigarette smoking on the risk of Parkinson's disease is one of the few consistent results in the epidemiology of this disorder. AmongExpand
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Seizures evoked from area tempestas are subject to control by GABA and glutamate receptors in substantia nigra
The functional relationship between the substantia nigra (SN) and the area tempestas (AT), an epileptogenic site in the deep prepiriform cortex, was investigated. Stimulation of GABA receptors in SNExpand
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Species differences in the role of excitatory amino acids in experimental parkinsonism
The present review discusses species differences in relation to the effects produced by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP); in particular, it focuses on recentExpand
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Thyroid disruptor 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) prevents internalization of TSH receptor
The thyroid-stimulating hormone (TSH) receptor (TSHr) was made specifically fluorescent by insertion of a tetracysteine motif (TSHr-FlAsH) into the C-terminal end and transiently transfected intoExpand
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