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Y chromosome evidence of earliest modern human settlement in East Asia and multiple origins of Tibetan and Japanese populations
It is proposed that D-M174 has a southern origin and its northward expansion occurred about 60,000 years ago, predating the northward migration of other major East Asian lineages. Expand
Global distribution of Y-chromosome haplogroup C reveals the prehistoric migration routes of African exodus and early settlement in East Asia
The phylogeographic distribution pattern of Hg C supports a single coastal ‘Out-of-Africa’ route by way of the Indian subcontinent, which eventually led to the early settlement of modern humans in mainland Southeast Asia. Expand
Extended Y chromosome investigation suggests postglacial migrations of modern humans into East Asia via the northern route.
It is proposed that although the Paleolithic migrations via the southern route played a major role in modern human settlement in East Asia, there are ancient contributions, though limited, from THE AUTHORS, which partly explain the genetic divergence between current southern and northern East Asian populations. Expand
Identification of Bphs, an Autoimmune Disease Locus, as Histamine Receptor H1
Congenic mapping links Bphs to the histamine H1 receptor gene (Hrh1/H1R) and that H1R differs at three amino acid residues in VAASH-susceptible and -resistant mice. Expand
Structures of a Human Papillomavirus (HPV) E6 Polypeptide Bound to MAGUK Proteins: Mechanisms of Targeting Tumor Suppressors by a High-Risk HPV Oncoprotein
The crystal structures of the complexes containing a peptide from HPV18 E6 bound to three PDZ domains from MAGI-1 and SAP97/Dlg reveal novel features of PDZ peptide recognition that explain why high-risk HPV E6 can specifically target these cellular tumor suppressors for destruction. Expand
Structure of the Epstein-Barr virus major envelope glycoprotein
Epstein-Barr virus (EBV) infection of B cells is associated with lymphoma and other human cancers. EBV infection is initiated by the binding of the viral envelope glycoprotein (gp350) to the cellExpand
A complete DNA sequence map of the ovine Major Histocompatibility Complex
The assembling of a complete DNA sequence map for the ovine MHC by shotgun sequencing of 26 overlapping BAC clones makes the sheep the second ruminant species for which the complete MHC sequence information is available for evolution and functional studies, following that of the bovine. Expand
Handmade cloned transgenic piglets expressing the nematode fat-1 gene.
This study used handmade cloning (HMC) established previously to produce transgenic pigs that express the functional nematode fat-1 gene, which effectively lowered the n-6/n-3 ratio in muscle and major organs of the transgenic pig. Expand
Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic
Experimental allergic encephalomyelitis (EAE), the principal animal model of multiple sclerosis, is genetically controlled. To date, 13 disease-modifying loci have been identified in the mouse byExpand
Detection of pectinesterase and polygalacturonase from salivary secretions of living greenbugs, Schizaphis graminum (Homoptera: Aphididae)
Pectinesterase and polygalacturonase were successfully detected in induced salivary secretions of living greenbugs, Schizaphis graminum, and the saliva of biotypes E and C contains both enzymes, providing conclusive evidence for the nature of secreted materials. Expand