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Antinociceptive and Antioxidant Activities of Phytol In Vivo and In Vitro Models
TLDR
Taken as a whole, these results show the pronounced antinociceptive effects of phytol in the nociception models used, both through its central and peripheral actions, but also its antioxidant properties demonstrated in the in vitro methods used. Expand
Oxidative stress in the hippocampus during experimental seizures can be ameliorated with the antioxidant ascorbic acid
TLDR
The hypothesis that oxidative stress in hippocampus occurs during seizures induced by pilocarpine is supported, proving that brain damage induced by the oxidative process plays a crucial role in seizures pathogenic consequences, and imply that a strong protective effect could be achieved using ascorbic acid. Expand
The systems containing clays and clay minerals from modified drug release: a review.
TLDR
This review summarizes bibliographic (articles) and technological information on the use of systems containing clays and clay minerals in modified drug delivery and the fields of technology and biopharmaceutical applications, where clays are applied. Expand
Comparative efficacy and toxic effects of carvacryl acetate and carvacrol on sheep gastrointestinal nematodes and mice.
TLDR
CA showed in vitro and in vivo anthelmintic activity and was less toxic than carvacrol, and caused more discreet effects on the cuticle and vulvar flap. Expand
Sedative, anxiolytic and antidepressant activities of Citrus limon (Burn) essential oil in mice.
TLDR
Sedative and anxiolytic effects of EO that might involve an action on benzodiazepine-type receptors, and also an antidepressant effect where noradrenergic and serotoninergic mechanisms will probably play a role are evidenced. Expand
Phytol in a pharma-medico-stance.
TLDR
Evidence shows PA to have cytotoxic, anticancer, antidiabetic, lipid lowering and aniteratogenic activities, and phytol may be considered as a new drug candidate. Expand
Mikania glomerata: Phytochemical, Pharmacological, and Neurochemical Study
TLDR
This extract demonstrated anxiolytic effects, which may be mediated by GABAergic system, and was able to increase GABA levels and reduce of glutamate and aspartate concentrations in mice hippocampus, which could represent an interesting therapeutical strategy in the treatment of anxiety. Expand
Antioxidant and Antinociceptive Effects of Citrus limon Essential Oil in Mice
TLDR
Whereas naloxone antagonized the antinociceptive action of EO (highest doses), this suggested, at least, the participation of the opioid system. Expand
Evaluation of central nervous system effects of iso-6-cassine isolated from Senna spectabilis var. excelsa (Schrad) in mice.
TLDR
ISO injected by oral route in mice caused a significant decrease in the motor activity of animals when compared with the control group, up to 30 days after the administration and at dose of 1.5mg/kg, it reduced the remaining time of animals on Rota-rod apparatus. Expand
Neuropharmacological effects of carvacryl acetate on δ-aminolevulinic dehydratase, Na+, K+-ATPase activities and amino acids levels in mice hippocampus after seizures.
TLDR
It is demonstrated that carvacryl acetate could be a future therapeutic option for treatment of epilepsy, with a multifactorial brain action mechanism. Expand
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