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Identification of Human Semiochemicals Attractive to the Major Vectors of Onchocerciasis
The identification of compounds attractive to the major vectors of O. volvulus will permit the development of optimized traps that may replace the use of human vector collectors for monitoring the effectiveness of onchocerciasis elimination programs and could find use in an integrated vector control/drug program aimed at eliminating river blindness in Africa. Expand
Synthetic analogues of the marine bisindole deoxytopsentin: potent selective inhibitors of MRSA pyruvate kinase.
As part of an ongoing study to elucidate the SAR of bisindole alkaloid inhibitors against the evolutionary conserved MRSA pyruvate kinase (PK), we present here the synthesis and biological activityExpand
Site-Specific Variability in the Chemical Diversity of the Antarctic Red Alga Plocamium cartilagineum
On the limited geographical range of this analysis, P. cartilagineum displays only modest genetic radiation, but its secondary metabolome was found to have experienced more extensive radiation, which may contribute to the discovery of cryptic speciation. Expand
Antiplasmodial activity: the first proof of inhibition of heme crystallization by marine isonitriles.
A cursory ab initio molecular dynamics investigation into the relative stabilities of bonded complexes between isocyanate, isothiocyanates and isonitrile groups with the iron center of heme supported the findings that these marine metabolites do indeed interfere with biocrystallization of he me. Expand
Capsaicin lowers plasma cholesterol and triglycerides of lagomorphs.
The data indicate that mammals of the order Lagomorpha fed cholesterol rich diets and supplemented with capsaicin show decreased plasma total cholesterol, triglycerides, and total cholesterol to HDL-C ratio as compared to cholesterol level of controls. Expand
Tolerance and sequestration of macroalgal chemical defenses by an Antarctic amphipod: a 'cheater' among mutualists
The amphipod Paradexamine fissicauda is able to consume Plocamium carti- lagineum and Picconiella plumosa, 2 species of sympatric, chemically defended red macroalgae, which are thought to exist together in a community-wide mutualism. Expand
The disruption of prenylation leads to pleiotropic rearrangements in cellular behavior in Staphylococcus aureus
It is demonstrated that this process is central to a wealth of pathways involved in mediating cellular homeostasis in S. aureus and an important characterization of prokaryotic prenylation is presented. Expand
Microwave-assisted selenium dioxide oxidation of aryl methyl ketones to aryl glyoxals
We report an improved procedure for the synthesis of phenyl glyoxal and a series of para-substituted aryl glyoxals by microwave-assisted selenium dioxide oxidation. The reaction time has been reducedExpand
Carbon dioxide generated from carbonates and acids for sampling blood-feeding arthropods.
Carbon dioxide (CO2) is utilized to attract mosquitoes and other blood-feeding arthropods to traps around the world. Commercial forms of CO2 (e.g., dry ice and compressed gas) are often unavailableExpand
Structure and Function of Macroalgal Natural Products.
In this chapter this chapter outlines the classes of metabolites produced by this chemically rich group of organisms as well as their respective ecological roles in the environment. Expand