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Tension responses to sudden length change in stimulated frog muscle fibres near slack length
1. Apparatus for applying a step change of length to an isolated muscle fibre is described. The step was complete in about 0·2 ms.
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Elasticity and unfolding of single molecules of the giant muscle protein titin
The giant muscle protein titin, also called connectin, is responsible for the elasticity of relaxed striated muscle, as well as acting as the molecular scaffold for thick-filament formation1,2. TheExpand
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The relation between stiffness and filament overlap in stimulated frog muscle fibres.
1. Tension transients were recorded at sarcomere lengths from 2.0 to 3.2 mum in isolated fibres from the tibialis anterior muscle of frogs during tetanic stimulation at 0‐1 degrees C. 2. The lengthExpand
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Models of motor-assisted transport of intracellular particles.
One-dimensional models are presented for the macroscopic intracellular transport of vesicles and organelles by molecular motors on a network of aligned intracellular filaments. A motor-coated vesicleExpand
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Quantitative measurements of force and displacement using an optical trap.
We combined a single-beam gradient optical trap with a high-resolution photodiode position detector to show that an optical trap can be used to make quantitative measurements of nanometerExpand
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Single-molecule biomechanics with optical methods.
Single-molecule observation and manipulation have come of age. With the advent of optical tweezers and other methods for probing and imaging single molecules, investigators have circumvented theExpand
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Control of sarcomere length in skinned muscle fibres of Rana temporaria during mechanical transients.
A new technique is described for high‐speed measurement of striation spacing of single skinned muscle fibres. A galvanometer mirror directs helium‐neon laser light on to the muscle fibre at aExpand
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Changes in the X-ray reflections from contracting muscle during rapid mechanical transients and their structural implications.
During normal contractions of vertebrate striated muscle, it is believed that the cross-bridges which produce the sliding force undergo asynchronous cyclical changes in their structure. Thus, anExpand
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Tension transients during steady shortening of frog muscle fibres.
Single intact fibres from frog muscle at 0‐1 degrees C were stimulated to produce isometric tetani at a sarcomere length of about 2.25 micron, using a spot‐follower apparatus to control the length ofExpand
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The elasticity of single titin molecules using a two-bead optical tweezers assay.
Titin is responsible for the passive elasticity of the muscle sarcomere. The mechanical properties of skeletal and cardiac muscle titin were characterized in single molecules using a novel dualExpand
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