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  • Christopher John Sneeringer, Margaret Porter Scott, +4 authors Robert A Copeland
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 2010 (First Published: 7 December 2010)
  • EZH2, the catalytic subunit of the PRC2 complex, catalyzes the mono- through trimethylation of lysine 27 on histone H3 (H3K27). Histone H3K27 trimethylation is a mechanism for suppressingContinue Reading
  • Sarah K. Knutson, Natalie M. Warholic, +11 authors Heike Keilhack
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences…
  • 2013 (First Published: 7 May 2013)
  • Inactivation of the switch/sucrose nonfermentable complex component SMARCB1 is extremely prevalent in pediatric malignant rhabdoid tumors (MRTs) or atypical teratoid rhabdoid tumors. This alterationContinue Reading
  • Liying Chen, Aniruddha Deshpande, +8 authors Scott A. Armstrong
  • Biology
  • 2012 (First Published: 16 November 2012)
  • Abstract 2384 The t(10;11)(p12;q23) and the t(10;11)(p12;q14), which encode the MLL-AF10 and CALM-AF10 fusion oncoproteins respectively, are two recurrent chromosomal rearrangements observed inContinue Reading