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Tumor-Specific Proteolytic Processing of Cyclin E Generates Hyperactive Lower-Molecular-Weight Forms
ABSTRACT Cyclin E is a G1 cyclin essential for S-phase entry and has a profound role in oncogenesis. Previously this laboratory found that cyclin E is overexpressed and present inExpand
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Activation of Cyclin-dependent Kinase 2 by Full Length and Low Molecular Weight Forms of Cyclin E in Breast Cancer Cells*
Cyclin E, a positive regulator of the cell cycle, controls the transition of cells from G1 to S phase. Deregulation of the G1-S checkpoint contributes to uncontrolled cell division, a hallmark ofExpand
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Processing of cyclin E differs between normal and tumor breast cells.
Cyclin E is a G1 cyclin essential for G1 to S-phase transition of the cell cycle with a profound role in oncogenesis. In tumor cells and tissues, cyclin E is overexpressed and present in its lowerExpand
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Requirements engineering standardization
As requirements engineering becomes more widespread, practitioners have learned what works and what does not work, as well as how to communicate among themselves and with other specialists, leadingExpand
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The anatomy of the engineering of a system relies on a uniform approach using an elemental “building block” approach. This approach is applicable at any layer in a system development, whether it beExpand
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2.4.1 Evolution of a Standard EIA-632 From 1994 to 2006
Process standards represent the best practices used by an industry or discipline. Most process standards are usually created by volunteer teams operating under the auspices of an authorized standardsExpand
The Requirements Management Working Group has established a Mission Statement to enhance understanding of its Charter and its objectives for NCOSE. From this, we have identified needed positionExpand