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A Novel Antinociceptive Sulphated Polysaccharide of the Brown Marine Alga Spatoglossum Schroederi
The data revealed for the first time the antinociceptive effect of Ss-SP which could be used as a new source of analgesic substances.
The leguminous lectin of Lonchocarpus araripensis promotes antinociception via mechanisms that include neuronal inhibition of Na+ currents
LAL inhibits peripheral hypernociceptive by mechanisms that involve the lectin domain, inflammatory mediators and Na+ channels, and the innovative inhibitory action of leguminous lectins on NaV current brings new insights for the investigation of sodium channels role in nociception.
Edematogenic activity of a sulfated galactan from the red marine algae Gelidium crinale
SG-Gc and λ carrageenan induce different profile of inflammatory response in the paw edema model, that involves histamine, cytokines, prostaglandins, and nitric oxide (NO), but with different degree of participation.
Antinociceptive effect of Lonchocarpus araripensis lectin: activation of l-arginine/NO/cGMP/K+ATP signaling pathway
LAL increased (95%) nNOS gene expression in mice paw tissues, but not its immunoexpression in the dorsal root ganglia, and LAL effect was reversed by nifedipine, niflumic acid, and glibenclamide, but was unaltered by aminoguanidine.
The Antinociceptive Effect of Lonchocarpus Araripensis Lectin is Mediated by Endocannabinoid Receptors
The involvement of endocannabinoid receptors in the antinociceptive activity of Lonchocarpus araripensis lectin was investigated in the model of carragenan-induced hypernociception and reversed the inhibitory effect of LAL.