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- Publications
- Influence
antiSMASH 3.0—a comprehensive resource for the genome mining of biosynthetic gene clusters
TLDR
Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature.
- P. Arnison, M. Bibb, +62 authors W. A. van der Donk
- Biology, Medicine
- Natural product reports
- 2013
This review presents recommended nomenclature for the biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs), a rapidly growing class of natural products. The… Expand
GeneTrail—advanced gene set enrichment analysis
- C. Backes, A. Keller, +6 authors Hans-Peter Lenhof
- Biology, Medicine
- Nucleic Acids Res.
- 25 May 2007
TLDR
Full-length RecE enhances linear-linear homologous recombination and facilitates direct cloning for bioprospecting
- Jun Fu, Xiaoying Bian, +8 authors Y. Zhang
- Biology, Medicine
- Nature Biotechnology
- 1 May 2012
Functional analysis of genome sequences requires methods for cloning DNA of interest. However, existing methods, such as library cloning and screening, are too demanding or inefficient for… Expand
Myxobacteria: proficient producers of novel natural products with various biological activities--past and future biotechnological aspects with the focus on the genus Sorangium.
- K. Gerth, S. Pradella, O. Perlova, S. Beyer, R. Müller
- Biology, Medicine
- Journal of biotechnology
- 19 December 2003
Myxobacteria are gram-negative bacteria which are most noted for their ability to form fruiting bodies upon starvation. Within the last two decades, they increasingly gained attention as producers of… Expand
Evolutionary implications of bacterial polyketide synthases.
- H. Jenke-Kodama, A. Sandmann, R. Müller, E. Dittmann
- Biology, Medicine
- Molecular biology and evolution
- 1 October 2005
Polyketide synthases (PKS) perform a stepwise biosynthesis of diverse carbon skeletons from simple activated carboxylic acid units. The products of the complex pathways possess a wide range of… Expand
The impact of bacterial genomics on natural product research.
"There's life in the old dog yet!" This adage also holds true for natural product research. After the era of natural products was declared to be over, because of the introduction of combinatorial… Expand
Recent developments towards the heterologous expression of complex bacterial natural product biosynthetic pathways.
The heterologous expression of natural product biosynthetic pathways is of increasing interest in biotechnology and drug discovery. It enables the (over)production of structurally complex substances… Expand
The unique DKxanthene secondary metabolite family from the myxobacterium Myxococcus xanthus is required for developmental sporulation
- P. Meiser, H. Bode, R. Müller
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 12 December 2006
Under starvation conditions myxobacteria form multicellular fruiting bodies in which vegetative cells differentiate into heat- and desiccation-resistant myxospores. Myxobacteria in general are a rich… Expand
Identification and analysis of the chivosazol biosynthetic gene cluster from the myxobacterial model strain Sorangium cellulosum So ce56.
- O. Perlova, K. Gerth, O. Kaiser, A. Hans, R. Müller
- Biology, Medicine
- Journal of biotechnology
- 24 January 2006
Myxobacteria belonging to the genus Sorangium are known to produce a variety of biologically active secondary metabolites. Chivosazol is a macrocyclic antibiotic active against yeast, filamentous… Expand