R. Müller

Publications13
h-index8
Citations538
Highly Influential Citations22
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Artemisia arborescens L essential oil-loaded solid lipid nanoparticles for potential agricultural application: Preparation and characterization
The aim of this study was to formulate a new delivery system for ecological pesticides by the incorporation of Artemisia arborescens L essential oil into solid lipid nanoparticles (SLN). Two… Expand
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Application of Novel Solid Lipid Nanoparticle (SLN)-Gene Vector Formulations Based on a Dimeric HIV-1 TAT-Peptide in Vitro and in Vivo
AbstractPurpose. To optimize gene delivery of SLN-based gene vectors by incorporation of a dimeric HIV-1 TAT peptide (TAT2) into SLN gene vectors. Methods. Plasmid DNA was complexed with two SLN… Expand
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Process optimization of a novel production method for nanosuspensions using design of experiments (DoE).
Particle size reduction is a suitable method to enhance the bioavailability of poorly soluble drugs. The reduction effectiveness depends on compound properties like crystallinity, hardness and… Expand
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Structural Characterization of Q10-Loaded Solid Lipid Nanoparticles by NMR Spectroscopy
AbstractPurpose. The structure of loaded solid lipid nanoparticles (SLN) has been studied to elucidate the incorporation of coenzyme Q10. Methods. Solid-state nuclear magnetic resonance (NMR) has… Expand
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Coenzyme Q10 oral bioavailability: effect of formulation type
Abstract Coenzyme Q10 (Q10) has a poor bioavailability due to its very low aqueous solubility and high molecular weight. The purpose of this review is to discuss the different types of Q10 drug… Expand
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Application of LIBD to the determination of the solubility product of thorium(IV)-colloids
A new experimental method is presented for the determination of solubility data, which is based on the laser-induced breakdown detection (LIBD). The method is capable of monitoring the initial… Expand
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Systematical investigation of a combinative particle size reduction technology for production of resveratrol nanosuspensions
Nanosizing is frequently used as formulation approach to increase the bioavailability of poorly water-soluble drugs. However, standard size reduction processes can be relatively time-consuming. It… Expand
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Preparation and storage stability of rutin nanosuspensions
Formulations of the rutin nanosuspensions have been prepared by high pressure homogenization (HPH). A Micron LAB 40 was used for HPH to obtain rutin nanosuspensions. Photon correlation spectroscopy… Expand
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Solubilizing poorly soluble antimy cotic agents by emulsification via a solvenent-free process
The purpose of this study was to formulate itraconazole and ketoconazole as oil/water emulsions for parenteral delivery by using a solvent-free homogenization process, namely SolEmuls (solubilization… Expand
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A novel concept for the treatment of couperosis based on nanocrystals in combination with solid lipid nanoparticles (SLN).
For the post laser treatment of couperosis a new dermal formulation was developed combining three actives: vitamin K1, A1 and rutin, where both vitamins were incorporated into solid lipid… Expand
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