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A Novel Coronavirus from Patients with Pneumonia in China, 2019
TLDR
Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily, which is the seventh member of the family of coronaviruses that infect humans. Expand
Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding
TLDR
The phylogenetic analysis suggests that bats might be the original host of this virus, an animal sold at the seafood market in Wuhan might represent an intermediate host facilitating the emergence of the virus in humans. Expand
Detection of SARS-CoV-2 in Different Types of Clinical Specimens.
This study describes results of PCR and viral RNA testing for SARS-CoV-2 in bronchoalveolar fluid, sputum, feces, blood, and urine specimens from patients with COVID-19 infection in China to identifyExpand
In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
TLDR
It is proposed that the immunomodulatory effect of hydroxychloroquine also may be useful in controlling the cytokine storm that occurs late-phase in critically ill SARS-CoV-2 infected patients. Expand
Origin and Possible Genetic Recombination of the Middle East Respiratory Syndrome Coronavirus from the First Imported Case in China: Phylogenetics and Coalescence Analysis
TLDR
The complete genomic sequence analysis of a MERS-CoV strain imported to China from South Korea suggests that the imported virus is a recombinant comprising group 3 and group 5 elements, and time-resolved phylogenetic estimation indicates that the recombination event likely occurred in the second half of 2014. Expand
Viral Etiology and Clinical Profiles of Children with Severe Acute Respiratory Infections in China
TLDR
Piconaviruses (EV/RV) and paramyxoviruses are the most popular viral pathogens among children with SARI in this study, and RSV and hMPV significantly increase the risk of SARI, especially in children younger than 24 months. Expand
Characterization of Human Coronavirus Etiology in Chinese Adults with Acute Upper Respiratory Tract Infection by Real-Time RT-PCR Assays
TLDR
All 4 non-SARS-associated HCoVs were more frequently detected by real-time RT-PCR assay in adults with URTI in Beijing and HCoV-229E led to the most prevalent infection. Expand
First infection by all four non-severe acute respiratory syndrome human coronaviruses takes place during childhood
TLDR
Large proportions of children and adults in Beijing have evidence of anti-S IgG against four the HCoVs, and first infections by all four non-SARS H coVs takes place during childhood. Expand
Etiology and Clinical Characterization of Respiratory Virus Infections in Adult Patients Attending an Emergency Department in Beijing
TLDR
The pattern of RV involvement in adults with ARTIs attending an ED in China differs from that previously reported, and the high prevalence of viruses (PIC, FluA, HCoVs and ADV) reported here strongly highlight the need for the development of safe and effective therapeutic approaches for these viruses. Expand
Scutellaria baicalensis extract and baicalein inhibit replication of SARS-CoV-2 and its 3C-like protease in vitro
TLDR
This study demonstrates that the extract of S. baicalensis has effective anti-SARS-CoV-2 activity and baicalein and analogue compounds are strong SARS- coV- 2 3CLpro inhibitors. Expand
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